FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PakGMR.Tag:Myr(Src64B)
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General Information
Symbol
Dmel\PakGMR.Tag:Myr(Src64B)
Species
D. melanogaster
Name
FlyBase ID
FBal0098337
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
P{GMR-Pak.myr}
Key Links
Transgenic product class
wild_type
(Hing et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hing et al., 1999)
Mutagen
in vitro construct
(Hing et al., 1999)
Progenitor genotype
PakGMR.PH
(Hing et al., 1999)
Carried in construct
P{GMR-Pak.myr}
Cytology
Description

The first 90 amino acids of Src64B are fused to the first codon of Pak as a myristylation signal.

(Hing et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
Pak
Tagged with
Tag:Myr(Src64B)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PakGMR.T:Myr1 exhibits a dose-dependent dominant phenotype. Wild type larvae carrying a single copy of PakGMR.T:Myr1 show mild clumping of axons in the lamina cortex. The R8 projections in the medulla and the pattern of R cells in the eye disc are normal. This defect is slightly enhanced in animals with two copies of PakGMR.T:Myr1. In larvae carrying four copies of PakGMR.T:Myr1, the R cell projection pattern is severely disrupted. In addition, the pattern of R cell clusters in the eye disc are highly abnormal; in these animals R cells delaminate from the eye disc epithelium and migrate through the optic stalk into the brain. Some cell bodies migrate as far as the medulla.

      (Hing et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      PakGMR.Tag:Myr(Src64B) is a suppressor of photoreceptor cell & axon phenotype of dockunspecified

      (Hing et al., 1999)

      PakGMR.Tag:Myr(Src64B) is a suppressor of lamina phenotype of dockunspecified

      (Hing et al., 1999)

      PakGMR.Tag:Myr(Src64B) is a suppressor of medulla phenotype of dockunspecified

      (Hing et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of PakGMR.T:Myr1 in dockunspecified larvae, suppresses the dock phenotype of gaps in the lamina, abnormal axon bundling and unexpanded growth cones in the medulla. Quantification of the expanded growth cones in the medulla showed an increase from less than 2 to 64+/-8 (136+/-12 in wild-type).

      (Hing et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      PakGMR.Tag:Myr(Src64B) rescues Pakunspecified

      (Hing et al., 1999)
      Comments

      A single copy of PakGMR.T:Myr1 rescues the Pak mutant phenotype.

      (Hing et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PakGMR.T:Myr-Src64B
      PakGMR.T:Myr1
      PakGMR.Tag:Myr(Src64B)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)