FB2026_02 , released June 18, 2026
Allele: Dmel\His2AvtM1
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General Information
Symbol
Dmel\His2AvtM1
Species
D. melanogaster
Name
FlyBase ID
FBal0098382
Feature type
allele
Associated gene
Dmel\His2Av
Associated Insertion(s)
Carried in Construct
P{His2AvDtM1}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Clarkson et al., 1999)
Progenitor genotype
His2Av+t4.0
(Clarkson et al., 1999)
Carried in construct
P{His2AvDtM1}
Cytology
Description

Amino acids 1-12 (AGGKSGKDSGKV) are replaced with amino acids 1-10 (SGRGKGGKV) of His2A. This region at the N terminal end, before the αN helix, is converted into the equivalent region in His2A.

(Clarkson et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
His2Av
Encoded product / tool
His2Av
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      His2AvtM1 partially rescues His2Av810

      (Clarkson et al., 1999)
      Comments

      The lethality associated with His2Av810 is partially rescued by His2AvtM1. At 25oC all flies reach pupariation, and about 50% of flies are rescued to adulthood. At 29oC about a third are rescued to adulthood.

      (Clarkson et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      His2AvtM1
      His2AvDtM1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)