FlyBase Allele Report: Dmel\Egfr[II.UAS]

General Information

Symbol

Dmel\Egfr^II.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0098853

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{UAS-Egfr.II}

Key Links

Transgenic product class

cDNA

(Shilo, 1999.8.22)

wild_type

(Shilo, 1999.8.22)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Shilo, 1999.8.22)

wild_type

(Shilo, 1999.8.22)

Mutagen

in vitro construct

(Shilo, 1999.8.22, Howes et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-Egfr.II}

Cytology

Description

Full length Egfr type II cDNA is expressed from UAS regulatory sequences. The type I and II cDNAs differ only in their 5' exon which encodes the signal peptide and a few residues following it.

(Shilo, 1999.8.22)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Egfr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^Bx-MS1096

(Howes et al., 1998)

visible, with Scer\GAL4^GMR.PF

(Casci et al., 1999)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Casci et al., 1999)

wing vein, with Scer\GAL4^Bx-MS1096

(Howes et al., 1998)

Detailed Description

Statement

Reference

Overexpression of Egfr^II.Scer\UAS in the developing wing blade using Scer\GAL4^Bx-MS1096 causes the formation of extra wing veins.

(Howes et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfr^II.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^II.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by sty[+]/sty^S88

(Casci et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^II.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by sty[+]/sty^S73

(Casci et al., 1999)

Egfr^II.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by sty[+]/sty^S88

(Casci et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype of flies expressing Egfr^II.Scer\UAS under the control of Scer\GAL4^GMR.PF is weakly dominantly enhanced by sty^S73 or sty^S88.

(Casci et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^btl.PS/Egfr^II.UAS rescues Egfr^f4

(Wappner et al., 1997)

Comments

Rescues the tracheal phenotype.

(Wappner et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

M. Golembo and E. Raz

(Shilo, 1999.8.22)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Egfr^II.Scer\UAS

Egfr^II.UAS

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close