FB2026_02 , released June 18, 2026
Allele: Dmel\vibS110416
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General Information
Symbol
Dmel\vibS110416
Species
D. melanogaster
Name
FlyBase ID
FBal0099923
Feature type
allele
Associated gene
Dmel\vib
Associated Insertion(s)
P{lacW}vibS110416
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
P-element activity
(Szeged Stock Center, 1998-)
Progenitor genotype
Associated Insertion(s)
P{lacW}vibS110416
Cytology
Description

Insertion within the first exon of the vib gene.

(Gatt and Glover, 2006)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      vibS110416/vibS110416 and vibS110416/Df(3R)Dl-BX12 mutant animals are both lethal during early pupal stage.

      Individual spermatids from vibS110416/Df(3R)Dl-BX12 males have multiple nuclei associated with an enlarged nebenkern in 80% of spermatids. These multinucleate spermatids undergo elongation, and multiple nuclei are seen associated with a bundle of axonemal fibres. Mutants show cytokinesis failure during male meiosis. The ring canal resulting from the first meiotic division appears larger than in wild-type, and in binucleate secondary spermatocytes the contractile rings appear disorganised.

      vibS110416/Df(3R)Dl-BX12 larval neuroblasts display a lower frequency of cell division compared to wild-type preparations.

      vibS045002c/vibS110416 mutants show cytokinesis failure during male meiosis.

      (Gatt and Glover, 2006)

      Lethality acts in the pupal and pharate adult stages.

      (Deak et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: A second site mutation.

      (Gatt and Glover, 2006)
      Comments
      Comments

      Based on the lethal stage of hemizygous alleles (over Df(3R)Dl-BX12), the following vib alleles can be ranked from strongest to weakest as follows: vibj7A3 > vibS110416 > vibEP513 = vibj5A6 > vibS045002c > vibEP651.

      (Gatt and Glover, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      1104/16
      (Deak et al., 1997)
      l(3)S110416S110416
      vibS110416
      (Gatt and Glover, 2006)
      Name Synonyms
      vibratorS110416
      (Gatt and Glover, 2006)
      Secondary FlyBase IDs
        References (3)