FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\zldG0353
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General Information
Symbol
Dmel\zldG0353
Species
D. melanogaster
Name
FlyBase ID
FBal0100309
Feature type
allele
Associated gene
Dmel\zld
Associated Insertion(s)
P{lacW}zldG0353
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Schäfer et al., 1999.8.12)
Progenitor genotype
Associated Insertion(s)
P{lacW}zldG0353
Cytology
Description

Insertion in the promoter region.

(Staudt et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ427024
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous embryos show multiple phenotypic effects in conjunction with embryonic or larval lethality. The embryos have segmentation defects (represented by fused segments) and strong abnormalities in the muscle pattern and in the peripheral and central nervous systems. The nervous system shows severe loss of neurons, disrupted axon tracks and misguided axons.

      (Staudt et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.8.12)

      Precise excision of the insertion reverts the mutant embryonic phenotype.

      (Staudt et al., 2006)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      l(1)G0353
      (Peter et al., 2002)
      l(1)G0353G0353
      vflG0353
      zldG0353
      Name Synonyms
      Secondary FlyBase IDs
        References (3)