FlyBase Allele Report: Dmel\salm[FCK-25]

General Information

Symbol

Dmel\salm^FCK-25

Species

D. melanogaster

Name

FlyBase ID

FBal0101169

Feature type

allele

Associated gene

Dmel\salm

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Barrio et al., 1999)

Progenitor genotype

Caused by aberration

T(2;3;4)FCK-25

Cytology

Description

Aberration breakpoint in a 5kb interval 5' of the salr coding region.

(Barrio et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Townes-Brocks syndrome

CEA with salr^FCK-25

(Si-Dong et al., 2003)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

second segment of antenna (with Df(2L)32FP-5)

(Dong et al., 2002)

third segment of antenna (with Df(2L)32FP-5)

(Dong et al., 2002)

Detailed Description

Statement

Reference

salm^FCK-25/Df(2L)32FP-5 transheterozygous animals exhibit an overall reduction in antennal segment 2 (a2). In addition a2 appears to be fused to a3 and a portion of the stalk that connects a2 to antennal segment 3 (a3) is exposed. The circular outline of the joint between antennal segments 2 and 3 is also lost. Furthermore a3 is unable to rotate in a2. salm¹⁶/salm^FCK-25 clones in the antenna appear normal.

(Dong et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

salm^FCK-25, salr^FCK-25 has abnormal auditory perception phenotype

(Si-Dong et al., 2003)

salm^FCK-25, salr^FCK-73/salr^FCK-25 has visible | recessive phenotype

(Barrio et al., 1999)

Df(2L)32FP-5/salr^FCK-25, salm^FCK-25 has visible | recessive phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-73 has visible | recessive phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-25 has visible | recessive phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-25 has visible | recessive phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-25 has visible | recessive phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-20 has visible | recessive phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-20/salr^FCK-25 has visible | recessive phenotype

(Barrio et al., 1999)

Phenotype Manifest In

Other

Statement

Reference

salm^FCK-25, salr^FCK-25 has scolopidium phenotype

(Si-Dong et al., 2003)

salm^FCK-25, salr^FCK-25 has third segment of antenna phenotype

(Si-Dong et al., 2003)

salm^FCK-25, salr^FCK-25 has Johnston organ phenotype

(Si-Dong et al., 2003)

salm^FCK-25, salr^FCK-25 has second segment of antenna phenotype

(Si-Dong et al., 2003)

salm^FCK-25, salr^FCK-25 has joint & antennal segment 2 & antennal segment 3 phenotype

(Si-Dong et al., 2003)

salm^FCK-25, salr^FCK-73/salr^FCK-25 has humeral bristle phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-73/salr^FCK-25 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-73/salr^FCK-25 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

Df(2L)32FP-5/salr^FCK-25, salm^FCK-25 has humeral bristle phenotype

(Barrio et al., 1999)

Df(2L)32FP-5/salr^FCK-25, salm^FCK-25 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

Df(2L)32FP-5/salr^FCK-25, salm^FCK-25 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-73 has humeral bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-73 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-73 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-25 has humeral bristle phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-25 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-25 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-25 has humeral bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-25 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-25 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-25 has humeral bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-25 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-73, salr^FCK-25 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-20 has humeral bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-20 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

salm^FCK-25/salm^FCK-20, salr^FCK-20 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-20/salr^FCK-25 has humeral bristle phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-20/salr^FCK-25 has anterior notopleural bristle phenotype

(Barrio et al., 1999)

salm^FCK-25, salr^FCK-20/salr^FCK-25 has prothoracic leg sensillum | ectopic phenotype

(Barrio et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

In T(2;3;4)FCK-25/Df(2L)32FP-5 mutant animals (T(2;3;4)FCK-25 cause the alleles salm^FCK-25 and salr^FCK-25) the Johnston's organs develop abnormally and degenerate during pupal stages. Scolopidia do differentiate but develop at reduced numbers and are highly disorganised, and by adulthood, some mutant antenna with no scolopidia are seen. The joint between antennal segments 2 and 3 is missing, these segments are also fused. As a consequence mutant animals have conductive hearing defects.

(Si-Dong et al., 2003)

100% of flies carrying T(2;3;4)FCK-25 and either Df(2L)FCK-20, In(2L)FCK-73 or Df(2L)32FP-5 lack the anterior notopleural macrochaetae and humeral chaetae, and ectopic chaetae are seen on the base of the first leg in 3.6%, 3.9% and 3.7% of flies respectively.

(Barrio et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

FCK-25

(Barrio et al., 1999)

sal^FCK-25

(Si-Dong et al., 2003)

salm^FCK-25

salmFCK-25

(Dong et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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