FlyBase Allele Report: Dmel\okr[A19-10]

General Information

Symbol

Dmel\okr^A19-10

Species

D. melanogaster

Name

FlyBase ID

FBal0101250

Feature type

allele

Associated gene

Dmel\okr

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: T to A. Amino acid replacement: V146D.

(Kooistra et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,992,216..2,992,216 [-]

Nucleotide change:

T2992216A

Reported nucleotide change:

T?A

Amino acid change:

V146D | okr-PA

Reported amino acid change:

V146D

(Kooistra et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive | recessive

(Kooistra et al., 1999)

female sterile

(Kooistra et al., 1999)

radiation sensitive | recessive

(Kooistra et al., 1999)

viable (with okr^17-11)

(Merigliano et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

okr^A19-10/Df(2L)JS17 and okr^A19-10/okr^17-11 mutants have the same methyl methanesulfonate and X ray hypersensitivity as okr^A19-10/Df(2L)JS17 mutants.

(Kooistra et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

okr^A19-10/okr^17-11 has radiation sensitive phenotype, enhanceable by Blm^D3/Blm^D2

(Kooistra et al., 1999)

Enhancer of

Statement

Reference

okr^A19-10/okr^17-11 is an enhancer of radiation sensitive phenotype of Blm^D3/Blm^D2

(Kooistra et al., 1999)

Other

Statement

Reference

okr^A19-10/okr^17-11, tws⁴³⁰ has lethal - all die before end of first instar larval stage phenotype

(Merigliano et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

okr^17-11/okr^A19-10 mus309^D2/mus309^D3 double mutants show a synergistic effect on sensitivity to X rays; the sensitivity is increased 40 fold compared to wild-type in double mutants. okr^17-11/okr^A19-10 mus309^D2/mus309^D3 double mutants do not show a synergistic effect on sensitivity to methyl methanesulfonate.

(Kooistra et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8525

okr^A19-10 cn¹ bw¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DmRAD54^A19-10

(Kooistra et al., 1999)

okr^A19-10

(Merigliano et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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