FlyBase Allele Report: Dmel\frtz[3]

General Information

Symbol

Dmel\frtz³

Species

D. melanogaster

Name

FlyBase ID

FBal0101417

Feature type

allele

Associated gene

Dmel\frtz

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

heat sensitive hypomorphic allele - genetic evidence

(Collier et al., 2005)

Mutagen

X ray

(Collier et al., 2005)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?C. Amino acid replacement: D375A.

(Collier et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:1,713,714..1,713,714 [-]

Nucleotide change:

G1713714C

Reported nucleotide change:

G?C

Amino acid change:

D375H | frtz-PA; D375H | frtz-PB; D375H | frtz-PD

Reported amino acid change:

D375A

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change

(Collier et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | heat sensitive

(Collier et al., 2005)

visible | heat sensitive

(Collier et al., 2005)

Phenotype Manifest In

wing hair | heat sensitive

(Collier et al., 2005)

wing hair | increased number | heat sensitive

(Collier et al., 2005)

Detailed Description

Statement

Reference

Weak, temperature sensitive allele. At 18^oC, homozygous and hemizygous flies have an almost wild-type wing hair phenotype. At 29^oC, mutants show moderate changes in wing hair polarity and number of wing hairs per cell compared to wild type.

(Collier et al., 2005)

Temperature-sensitive allele.

(Roote, 1999.11.22)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

frtz³ has visible phenotype, enhanceable by in^II53

(Collier et al., 2005)

frtz³ has abnormal planar polarity phenotype, enhanceable by in^II53

(Collier et al., 2005)

frtz³ has abnormal planar polarity phenotype, enhanceable by fy⁵

(Collier et al., 2005)

frtz³ has visible phenotype, enhanceable by fy⁵

(Collier et al., 2005)

Enhancer of

Statement

Reference

frtz³ is an enhancer of abnormal planar polarity phenotype of fy⁵

(Collier et al., 2005)

frtz³ is an enhancer of visible phenotype of fy⁵

(Collier et al., 2005)

frtz³ is an enhancer of abnormal planar polarity phenotype of in^II53

(Collier et al., 2005)

frtz³ is an enhancer of visible phenotype of in^II53

(Collier et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

frtz³ has wing hair | increased number phenotype, enhanceable by fy⁵

(Collier et al., 2005)

frtz³ has wing hair phenotype, enhanceable by fy⁵

(Collier et al., 2005)

frtz³ has wing hair | increased number phenotype, enhanceable by in^II53

(Collier et al., 2005)

frtz³ has wing hair phenotype, enhanceable by in^II53

(Collier et al., 2005)

Enhancer of

Statement

Reference

frtz³/frtz[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4^en.PU, cmb^{UAS.RA.Tag:FLAG}

(Fagan et al., 2014)

frtz³ is an enhancer of wing hair | increased number phenotype of fy⁵

(Collier et al., 2005)

frtz³ is an enhancer of wing hair phenotype of fy⁵

(Collier et al., 2005)

frtz³ is an enhancer of wing hair | increased number phenotype of in^II53

(Collier et al., 2005)

frtz³ is an enhancer of wing hair phenotype of in^II53

(Collier et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity significantly enhances the multiple hair cell phenotype of Scer\GAL4^en.PU cmb^Scer\UAS.RA wings.

(Fagan et al., 2014)

At 18^oC, in^II53 frtz³ double mutants have strong mutant polarity and hair number phenotypes in the wing hairs (while either single mutant has an almost wild-type wing hair phenotype at this temperature). At 18^oC, fy⁵ frtz³ double mutants have strong mutant polarity.

(Collier et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5456

frtz³ P{neoFRT}42D cn¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

GJ66/78

(Collier et al., 2005)

fritz³

(Collier et al., 2005)

frtz³

(Fagan et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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