FlyBase Allele Report: Dmel\fy[5]

General Information

Symbol

Dmel\fy⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0082917

Feature type

allele

Associated gene

Dmel\fy

Associated Insertion(s)

Carried in Construct

Also Known As

fy^JN11

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Collier and Gubb, 1997)

Mutagen

ethyl methanesulfonate

(Collier and Gubb, 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: ?331term.

(Collier and Gubb, 1997)

Mutation is predicted to produce a protein lacking the fourth putative membrane domain.

(Collier and Gubb, 1997)

Nucleotide substitution: C?T.

(Collier and Gubb, 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:8,402,033..8,402,033 [-]

Nucleotide change:

C8402033T

Reported nucleotide change:

C?T

Amino acid change:

Q331term | fy-PA; Q331term | fy-PB

Reported amino acid change:

?331term

(Collier and Gubb, 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Collier and Gubb, 1997)

Phenotype Manifest In

wing & trichome

(Collier and Gubb, 1997)

Detailed Description

Statement

Reference

Mutant flies have an almost wild-type wing hair phenotype at 18^oC.

(Collier et al., 2005)

Flies show mild deviations from normal wing hair polarity and a low incidence of wing cells having extra hairs.

(Collier and Gubb, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fy⁵ has abnormal planar polarity phenotype, enhanceable by frtz³

(Collier et al., 2005)

fy⁵ has visible phenotype, enhanceable by frtz³

(Collier et al., 2005)

Enhancer of

Statement

Reference

fy⁵ is an enhancer of abnormal planar polarity phenotype of frtz³

(Collier et al., 2005)

fy⁵ is an enhancer of visible phenotype of frtz³

(Collier et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

fy⁵ has wing hair | increased number phenotype, enhanceable by frtz³

(Collier et al., 2005)

fy⁵ has wing hair phenotype, enhanceable by frtz³

(Collier et al., 2005)

fy⁵ has wing hair phenotype, enhanceable by fz²⁴

(Lee and Adler, 2002)

Enhancer of

Statement

Reference

fy⁵ is an enhancer of wing hair | increased number phenotype of frtz³

(Collier et al., 2005)

fy⁵ is an enhancer of wing hair phenotype of frtz³

(Collier et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

At 18^oC, fy⁵ frtz³ double mutants have strong mutant polarity and hair number phenotypes in the wing hairs (while either single mutant has an almost wild-type wing hair phenotype at this temperature).

(Collier et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fy⁵

fy^JN11

(Chung et al., 2007, Lee and Adler, 2002, Collier and Gubb, 1997)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close