FlyBase Allele Report: Dmel\retn[UAS.cSa]

General Information

Symbol

Dmel\retn^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Shandala

FlyBase ID

FBal0101449

Feature type

allele

Associated gene

Dmel\retn

Associated Insertion(s)

Carried in Construct

P{UAS-dri.S}

Also Known As

UAS-dri

Key Links

Transgenic product class

cDNA

(Shandala et al., 1999)

wild_type

(Shandala et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Shandala et al., 1999)

wild_type

(Shandala et al., 1999)

Mutagen

in vitro construct

(Shandala et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-dri.S}

Cytology

Description

A full length retn cDNA is expressed under the control of UASt regulatory sequences.

(Shandala et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

retn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^MZ1580

(Shandala et al., 2003)

Phenotype Manifest In

axon, with Scer\GAL4^MZ1580

(Shandala et al., 2003)

embryonic hindgut, with Scer\GAL4^byn-Gal4

(Iwaki and Lengyel, 2002)

larval glial cell, with Scer\GAL4^MZ1580

(Shandala et al., 2003)

Detailed Description

Statement

Reference

Expression of retn^Scer\UAS.cSa in embryos under the control of Scer\GAL4^sim.PS does not induce longitudinal glia cell fate specification. Expression of retn^Scer\UAS.cSa in embryos under the control of Scer\GAL4^Kr.PM does not prevent normal neural differentiation in the central and peripheral nervous system. Expression of retn^Scer\UAS.cSa in embryos under the control of Scer\GAL4^MZ1580 interferes with normal glial development and results in severe defasciculation of axons.

(Shandala et al., 2003)

Hindgut boundary cell rows and rings are still present in embryos expressing retn^Scer\UAS.cSa under the control of Scer\GAL4^byn-Gal4 and they appear largely normal (the boundary cell rows appear slightly crooked).

(Iwaki and Lengyel, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

retn^UAS.cSa/Scer\GAL4^retn-89.GAL4 rescues retn^89.GAL4/retn^RU50

(Ditch et al., 2005)

retn^UAS.cSa/Scer\GAL4^retn-89.GAL4 rescues retn^89.GAL4/retn^z2-428

(Ditch et al., 2005)

Partially rescues

retn^UAS.cSa/Scer\GAL4^retn-GAL4 partially rescues retn^GAL4/Df(2R)tid

(Shandala et al., 1999)

Comments

retn^Scer\UAS.cSa driven by Scer\GAL4^retn.89, rescues the partial lethality seen in retn^z2-428/retn^89.GAL4 animals and the female resistance to male courtship seen in retn^RU50/retn^89.GAL4 animals.

(Ditch et al., 2005)

Variably rescues the embryonic lethality of retn^GAL4/Df(2R)tid animals.

(Shandala et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dri^Scer\UAS.cSa

(Shandala et al., 1999)

retn^Scer\UAS.cSa

retn^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Shandala

(Shandala et al., 1999)

Secondary FlyBase IDs

References (4)

Report Sections

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