FlyBase Allele Report: Dmel\lola[c46]

General Information

Symbol

Dmel\lola^c46

Species

D. melanogaster

Name

FlyBase ID

FBal0102517

Feature type

allele

Associated gene

Dmel\lola

Associated Insertion(s)

Carried in Construct

Also Known As

lola^ORC46

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

chemical

(Madden et al., 1999)

ethyl methanesulfonate

(Crowner et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: E304term.

(Horiuchi et al., 2003)

Nucleotide substitution: T10735C.

(Horiuchi et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:10,532,553..10,532,553 [-]

Nucleotide change:

C10532553T

Reported nucleotide change:

C10735T

Amino acid change:

Reported amino acid change:

Q304term

(Horiuchi et al., 2003, Crowner et al., 2002, Madden et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Horiuchi et al., 2003)

abnormal neuroanatomy (with lola^e76)

(Crowner et al., 2002)

abnormal neuroanatomy | somatic clone

(Hattori et al., 2013)

lethal (with Df(2R)stan2)

(Horiuchi et al., 2003)

lethal (with lola^ORE120)

(Horiuchi et al., 2003)

lethal | recessive

(Horiuchi et al., 2003)

partially lethal (with lola^ORC4)

(Horiuchi et al., 2003)

partially lethal (with lola^ORE119)

(Horiuchi et al., 2003)

viable (with lola^ORE50)

(Horiuchi et al., 2003)

Phenotype Manifest In

abdominal dorsal multidendritic neuron ddaC | somatic clone | third instar larval stage

(Hattori et al., 2013)

abdominal dorsal multidendritic neuron ddaD | somatic clone | third instar larval stage

(Hattori et al., 2013)

abdominal dorsal multidendritic neuron ddaE | somatic clone | third instar larval stage

(Hattori et al., 2013)

axon (with lola^e76)

(Crowner et al., 2002)

dendritic tree | somatic clone | third instar larval stage

(Hattori et al., 2013)

larval abdominal segmental nerve

(Madden et al., 1999)

larval intersegmental nerve

(Madden et al., 1999)

larval longitudinal connective

(Madden et al., 1999)

muscle cell of A1-7 ventral longitudinal muscle 1

(Madden et al., 1999)

muscle cell of A1-7 ventral longitudinal muscle 2

(Madden et al., 1999)

muscle cell of A1-7 ventral longitudinal muscle 3

(Madden et al., 1999)

muscle cell of A1-7 ventral longitudinal muscle 4

(Madden et al., 1999)

Detailed Description

Statement

Reference

Class I abdominal dorsal multidendritic ddaD and ddaE neurons from lola^c46 mutant somatic clones in third instar larvae present a significant decrease in the number of dendrite branch terminals, as compared to controls.

Class IV abdominal dorsal multidendritic ddaC neurons from lola^c46 mutant somatic clones in third instar larvae present dendrite branch terminals of similar number but of significantly lower average length, as compared to controls.

(Hattori et al., 2013)

ap-positive axons cross the midline in lola^c46/lola^e76 embryos, in contrast to wild type. These axons then stall when they reach the mediolateral position where the contralateral connective would be found in wild-type embryos. Axons of the pCC and MP1 neurons do not cross the midline in these embryos. Midline glia cells are present in lola^c46 embryos.

(Crowner et al., 2002)

Mutants have CNS longitudinal interruptions, ISN stalling and failure of SNb innervation. In mutant embryos neuronal and muscle cell identities are normal, though with low penetrance ventral longitudinal muscles can be missing.

(Madden et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

lola^ORC4

(Horiuchi et al., 2003)

lola^ORE119

(Horiuchi et al., 2003)

lola^ORE50

(Horiuchi et al., 2003)

Fails to complement

lola^5D2

(Horiuchi et al., 2003)

lola^ORE120

(Horiuchi et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

lola^C46

(Hattori et al., 2013)

lola^ORC46

(Horiuchi et al., 2003, Crowner et al., 2002)

lola^ORE46

(Kuzin et al., 2005)

lola^c46

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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