FB2026_02 , released June 18, 2026
Allele: Dmel\howS.UAS
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General Information
Symbol
Dmel\howS.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0102689
Feature type
allele
Associated gene
Dmel\how
Associated Insertion(s)
Carried in Construct
P{UAS-how.S}
Also Known As
UAS-How(S)
Key Links
Transgenic product class
cDNA
(Nabel-Rosen et al., 1999)
wild_type
(Nabel-Rosen et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Nabel-Rosen et al., 1999)
wild_type
(Nabel-Rosen et al., 1999)
Mutagen
in vitro construct
(Nabel-Rosen et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-how.S}
Cytology
Description

The how S cDNA is expressed under the control of UASt regulatory sequences.

(Nabel-Rosen et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
how
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of howS.Scer\UAS in early germline stem cells under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 does not affect development.

      (Monk et al., 2010)

      Expression of howS.Scer\UAS under the control of Scer\GAL4sd.PU results in a reduction in wing size and the formation of the anterior wing margin is affected.

      (Edenfeld et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4sd.PU, howS.UAS has visible phenotype, enhanceable by Scer\GAL4sd.PU/crnUAS.cEa

      (Edenfeld et al., 2006)
      Suppressed by
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4sd.PU, howS.UAS has wing phenotype, suppressible | partially by crn[+]/crnunspecified

      (Edenfeld et al., 2006)

      Scer\GAL4sd.PU, howS.UAS has wing phenotype, suppressible | partially by crnUAS.Tag:Myr(Src64B)/Scer\GAL4sd.PU

      (Edenfeld et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      crnunspecified/+ partially rescues the reduced wing size caused by expression of howS.Scer\UAS under the control of Scer\GAL4sd.PU.

      Co-expression of crnScer\UAS.cEa enhances the reduction in wing size and the phenotype of defects in anterior wing margin seen in flies expressing howS.Scer\UAS under the control of Scer\GAL4sd.PU.

      Co-expression of crnScer\UAS.T:Myr1 partially suppresses the reduction in wing size seen in flies expressing howS.Scer\UAS under the control of Scer\GAL4sd.PU.

      (Edenfeld et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4VP16.nanos.UTR/howS.UAS rescues howr17/howr4

      (Monk et al., 2010)
      Comments

      Expression of howS.Scer\UAS in early germline stem cells under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 rescues the howr17/howr4 germline stem cell phenotype.

      (Monk et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      howS.Scer\UAS
      howS.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)