FlyBase Allele Report: Dmel\dos[Y854F.hs.2sev]

General Information

Symbol

Dmel\dos^{Y854F.hs.2sev}

Species

D. melanogaster

Name

FlyBase ID

FBal0102749

Feature type

allele

Associated gene

Dmel\dos

Associated Insertion(s)

Carried in Construct

P{sE-dos^Y854F}

Key Links

Transgenic product class

missense_variant

(Herbst et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Herbst et al., 1999)

Mutagen

in vitro construct

(Herbst et al., 1999)

Progenitor genotype

Carried in construct

P{sE-dos^Y854F}

Cytology

Description

A duplicated sev enhancer and Hsp70 promoter drive expression of a dos cDNA that has been mutated to carry the Y854F amino acid replacement.

(Herbst et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

dos

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye

(Herbst et al., 1999)

eye photoreceptor cell

(Herbst et al., 1999)

ommatidium

(Herbst et al., 1999)

photoreceptor cell R7

(Herbst et al., 1999)

Detailed Description

Statement

Reference

Flies carrying two copies of dos^Y801F.sev.hs have moderately rough eyes. These eyes frequently lack R7 cells and occasionally lack one or two of the R1-R6 class photoreceptors.

(Herbst et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

dos^{Y854F.hs.2sev} is a suppressor of ommatidium phenotype of sev^S11.Tag:MYC

(Herbst et al., 1999)

dos^{Y854F.hs.2sev} is a suppressor of eye phenotype of sev^S11.Tag:MYC

(Herbst et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of dos^Y854F.sev.hs suppresses the rough eye phenotype seen in sev^{S11.T:Hsap\MYC} flies.

(Herbst et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DOS^Y854F

(Herbst et al., 1999)

dos^{Y854F.hs.2sev}

dos^Y854F.sev.hs

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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