FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dosY810F.Y854F.hs.2sev
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General Information
Symbol
Dmel\dosY810F.Y854F.hs.2sev
Species
D. melanogaster
Name
FlyBase ID
FBal0102751
Feature type
allele
Associated gene
Dmel\dos
Associated Insertion(s)
Carried in Construct
P{sE-dosY810F.Y854F}
Key Links
Transgenic product class
missense_variant
(Herbst et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Herbst et al., 1999)
Mutagen
in vitro construct
(Herbst et al., 1999)
Progenitor genotype
Carried in construct
P{sE-dosY810F.Y854F}
Cytology
Description

A duplicated sev enhancer and Hsp70 promoter drive expression of a dos cDNA that has been mutated to carry the Y810F and Y854F amino acid replacements.

(Herbst et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
sev
Encoded product / tool
dos
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      dosY810F.Y854F.hs.2sev is a suppressor of ommatidium phenotype of sevS11.Tag:MYC

      (Herbst et al., 1999)

      dosY810F.Y854F.hs.2sev is a suppressor of eye phenotype of sevS11.Tag:MYC

      (Herbst et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of dosY810F.Y854F.sev.hs suppresses the rough eye phenotype seen in sevS11.T:Hsap\MYC flies.

      (Herbst et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DOSY810F,Y854F
      (Herbst et al., 1999)
      dosY810F.Y854F.hs.2sev
      dosY810F.Y854F.sev.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)