FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\ci5m.UAS
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General Information
Symbol
Dmel\ci5m.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0102788
Feature type
allele
Associated gene
Dmel\ci
Associated Insertion(s)
Carried in Construct
P{UAS-ci.5m}
Also Known As
UAS-ci5m
Key Links
Transgenic product class
missense_variant
(Price and Kalderon, 1999)
polypeptide_post_translational_processing_variant
(Price and Kalderon, 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Price and Kalderon, 1999)
polypeptide_post_translational_processing_variant
(Price and Kalderon, 1999)
Mutagen
in vitro construct
(Price and Kalderon, 1999)
Progenitor genotype
Carried in construct
P{UAS-ci.5m}
Cytology
Description

A mutated form of ci (with mutations in the potential PKA phosphorylation sites 1, 2, 3, A and B) is expressed under the control of UASt regulatory sequences. The amino acid changes are S838A, S855A, S856A, S891A, S892A, S962A and T1006A.

(Price and Kalderon, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ci
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by HipkUAS.Tag:HA
      (Blaquiere et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing ci5m.UAS under the control of Scer\GAL4dpp.blk1 leads to misshapen wing discs; cells originating from the wing disc's Dpp-positive domain show an invasive phenotype.

      (Blaquiere et al., 2018)

      Overexpression of ci5m.Scer\UAS behind the morphogenetic furrow, under the regulation of Scer\GAL4lz-gal4 causes loss of ommatidial bristles (40-50%) and mildly disordered ommatidial packing. The corresponding pupal ommatidia show occasional loss of cone cells (2%), failure of the primary cells to wrap around the equatorial cone cells (12%), and excess lattice cells (38%). Photoreceptor differentiation, assessed by counting rhabdomeres in pupal retinas, is unaffected in these mutants.

      (Kent et al., 2006)

      When expression is driven in the ovarioles by heat shock invoked Scer\GAL4Act5C.PP expression, massive overproliferation of stalk cells occurs.

      (Zhang and Kalderon, 2001)

      Percentage embryonic lethality in lines expressing ciScer\UAS.cPa under the control of various Scer\GAL4 driver lines: 48% (Scer\GAL4e22c driver), 86% (Scer\GAL4ptc-559.1 driver) and 36% (Scer\GAL4en-e16E driver). Percentage larval/pupal lethality in lines expressing ciScer\UAS.cPa under the control of Scer\GAL471B : 71%.

      (Price and Kalderon, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ci5m.Scer\UAS
      ci5m.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (7)