FlyBase Allele Report: Dmel\Diap1[6-3s]

General Information

Symbol

Dmel\Diap1^6-3s

Species

D. melanogaster

Name

FlyBase ID

FBal0103512

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: G88S.

(Wilson et al., 2002)

Amino acid replacement: G88S. This mutation is within the first BIR domain.

(Goyal et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,039,727..16,039,727 [-]

Nucleotide change:

G16039727A

Amino acid change:

Reported amino acid change:

G88S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Goyal et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Kuo et al., 2006)

decreased cell death | adult stage

(Lee et al., 2013)

partially lethal - majority die | recessive

(Goyal et al., 2000)

Phenotype Manifest In

dendrite

(Kuo et al., 2006)

neuron

(Kuo et al., 2006)

peptidergic neuron | adult stage | ectopic

(Lee et al., 2013)

Detailed Description

Statement

Reference

The programmed cell death of bursCCAP neurons seen in the adult ventral nerve cord of wild type flies after eclosion is partially suppressed in th^6-3s mutant homozygotes. An average of four bursCCAP neurons are seen at 3-5 days.

(Lee et al., 2013)

th^6-3s mutant C4da neurons appear to develop dendrites as normal throughout the larval stage. However, unlike wild-type C4da neurons that completely prune their larval dendrites by 18 hours after puparium formation, C4da neurons in th^6-3s mutants fail to efficiently sever larval dendrites at 18 hours after puparium formation.

(Kuo et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Diap1^6-3s/th[+] is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, rpr^{UTR.UAS.Tag:HA}

(Sandu et al., 2010)

Diap1^6-3s/th[+] is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, rpr^LZ.UAS

(Sandu et al., 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

Diap1^6-3s/th[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, rpr^{UTR.UAS.Tag:HA}

(Sandu et al., 2010)

Diap1^6-3s/th[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, rpr^LZ.UAS

(Sandu et al., 2010)

Diap1^6-3s is a suppressor of phenotype of hid^GMR.PG

(Goyal et al., 2000)

Diap1^6-3s is a suppressor of phenotype of rpr^GMR.PW

(Goyal et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

A th^6-3s heterozygous background significantly suppresses apoptosis induced by expression of rpr^{UTR.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Sandu et al., 2010)

Addition of th^6-3s strongly suppresses the phenotype seen in rpr^GMR.PW and W^GMR.PG flies.

(Goyal et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DIAP1^6-3s

(Lee et al., 2013)

Diap1^6-3s

diap1^6-3s

(Sandu et al., 2010, Kuo et al., 2006)

th^6-3s

(Lee et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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