FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grkΔC
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General Information
Symbol
Dmel\grkΔC
Species
D. melanogaster
Name
FlyBase ID
FBal0103805
Feature type
allele
Associated gene
Dmel\grk
Associated Insertion(s)
Carried in Construct
P{grk.ΔC}
Key Links
Transgenic product class
missense_variant
(Queenan et al., 1999)
stop_gained
(Queenan et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Queenan et al., 1999)
stop_gained
(Queenan et al., 1999)
Mutagen
in vitro construct
(Queenan et al., 1999)
Progenitor genotype
grk+t9
(Queenan et al., 1999)
Carried in construct
P{grk.ΔC}
Cytology
Description

A Stop codon is inserted 6 amino acids after the transmembrane domain (replacing residue Y276). The last amino acid before the stop is also changed (amino acid replacement I275R). The truncated cDNA is driven by a 5kb grk genomic fragment.

(Queenan et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
grk
Encoded product / tool
grk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      grkΔC rescues grk2B6/grk2E12

      (Herpers and Rabouille, 2004)
      Partially rescues

      grkΔC partially rescues grk2B6

      (Queenan et al., 1999)
      Comments

      The addition of one copy of grkΔC into a homozygous grk2B6 background produces mothers whose eggs are rescued almost to wild-type (both anterior posterior and dorsal ventral defects are rescued). All embryos have aeropyles, and less than 1/4 of the sets of dorsal appendages are fused. Extra copies led to dorsalisation of the egg.

      (Queenan et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      grkΔC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)