FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BrdUAS.cLa
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General Information
Symbol
Dmel\BrdUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lai
FlyBase ID
FBal0104351
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of the coding region and a few nucleotides of 5' UTR sequence (to provide translational initiation context) of Brd.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing BrdScer\UAS.cLa under the control of Scer\GAL4sca-537.4 show defects in the adult peripheral nervous system, including tufting (multiplication) of many head macrochaetae and some notum macrochaetae, frequent doubling or mild tufting of up to a third of notum microchaetae and mild increases in the density of microchaetae. Flies expressing high levels of BrdScer\UAS.cLa under the control of Scer\GAL4ey.PS show strong defects in ommatidial assembly and organisation, showing substantial ommatidial fusion and lens pitting in the eye. Flies expressing BrdScer\UAS.cLa under the control of Scer\GAL4GMR.PF have strongly roughened eyes with defects that include tufting of interommatidial bristles and excess photoreceptors. Expression of BrdScer\UAS.cLa under the control of either Scer\GAL4Bx-MS1096 or Scer\GAL469B does not appear to alter wing vein fates or the overall integrity of the wing margin, although sensory organ fates in each of these territories are altered.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
BrdScer\UAS.cLa
BrdUAS.cLa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Lai
Secondary FlyBase IDs
    References (1)