FB2026_02 , released June 18, 2026
Allele: Dmel\SharkK698R.hs
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General Information
Symbol
Dmel\SharkK698R.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0104429
Feature type
allele
Associated gene
Dmel\Shark
Associated Insertion(s)
Carried in Construct
P{hs-Shark.K698R}
Key Links
Transgenic product class
missense_variant
(Fernandez et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Fernandez et al., 2000)
Mutagen
in vitro construct
(Fernandez et al., 2000)
Progenitor genotype
Carried in construct
P{hs-Shark.K698R}
Cytology
Description

An Hsp70 promoter drives expression of a catalytically inactive form of Shark.

(Fernandez et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Shark
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      SharkK698R.hs is a non-suppressor of embryonic/first instar larval cuticle | dorsal | germline clone phenotype of DokPG155

      (Biswas et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of the sharkK698R.hs transgene fails to rescue DokPG155 germ-line clone embryos.

      (Biswas et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      SharkK698R.hs fails to rescue Shark1

      (Fernandez et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid and transfected into S2 cells to confirm loss of catalytic activity of the sharkK698R.hs product.

      (Fernandez et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SharkK698R.hs
      sharkK698R.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (2)