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General Information
Symbol
Dmel\HemG1-37
Species
D. melanogaster
Name
FlyBase ID
FBal0105157
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
KetteG1-37
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

A22286987T

Amino acid change:

H334L | Hem-PA

Reported amino acid change:

H334L

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: H334L.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

HemJ4-48/HemG1-37 transheterozygote embryos display defects in the number, migration and morphology of visceral longitudinal muscle founder cells.

Unfused myoblasts are apparent in HemG1-37 mutant embryos until stage 15. By stage 16 hardly any unfused myoblasts are present, but there are large gaps in the muscle pattern and epidermal-muscle attachments are frequently missing or incorrect. Dorsal closure is normal in these embryos, as is formation of the dorsal vessel and cardioblasts.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

HemG1-37 has somatic muscle primordium phenotype, enhanceable by blow[+]/blow2

NOT Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The reduction of myoblast fusion seen in stage 15 HemG1-37/HemG1-37 embryos is enhanced by blow2/+. The muscle fusion phenotype of double homozygous blow2; HemG1-37 embryos resembles that of blow2 homozygotes rather than HemG1-37 homozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Allelic series based on mutant phenotype; HemC3-20 = HemJ4-48 > HemP168 > HemG1-37 > HemJ1-70.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)