FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\triounspecified
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General Information
Symbol
Dmel\triounspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0117274
Feature type
allele
Associated gene
Dmel\trio
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        embryonic central nervous system & axon

        (Hakeda-Suzuki et al., 2002)

        embryonic peripheral nervous system & axon

        (Hakeda-Suzuki et al., 2002)

        eye photoreceptor cell | somatic clone

        (Newsome et al., 2000)
        Detailed Description
        Statement
        Reference

        The initial stages of mesoderm spreading during mesoderm morphogenesis are normal in mutant embryos.

        (Wilson et al., 2005)

        Embryos lacking both maternal and zygotic trio function show severe axon stalling defects in both the CNS and PNS.

        (Hakeda-Suzuki et al., 2002)

        Homozygous null trio animals either fail to hatch or die as first instar larvae. Mosaic animals in which virtually the entire retina is homozygous for triounspecified while other tissues are heterozygous (clones generated using the "eyFLP" system) correctly form photoreceptors into ommatidial clusters with the normal dorsal-ventral polarity and mirror image symmetry across the equator. Rhabdomeres have normal morphology, orientation and trapezoidal arrangement. The only retina defect that can be detected is the occasional absence of a single outer photoreceptor.

        (Newsome et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        triounspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (5)