FlyBase Allele Report: Dmel\stg[UASp.cMa]

General Information

Symbol

Dmel\stg^UASp.cMa

Species

D. melanogaster

Name

FlyBase ID

FBal0117336

Feature type

allele

Associated gene

Dmel\stg

Associated Insertion(s)

Carried in Construct

P{UASp-stg.M}

Key Links

Transgenic product class

wild_type

(Mata et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Mata et al., 2000)

Mutagen

in vitro construct

(Mata et al., 2000)

Progenitor genotype

Carried in construct

P{UASp-stg.M}

Cytology

Description

UASp regulatory sequences drive expression of stg.

(Mata et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

stg

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cyst cell of ovary, with Scer\GAL4^{VP16.nanos.UTR}

(Mata et al., 2000)

germline cyst, with Scer\GAL4^{VP16.nanos.UTR}

(Mata et al., 2000)

oocyte, with Scer\GAL4^{VP16.nanos.UTR}

(Mata et al., 2000)

Detailed Description

Statement

Reference

Overexpression of stg^{Scer\UAS.P\T.cMa} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} results in 8-cell cysts in approximately 18% of egg chambers. The oocyte is normal in about half of the 8-cell cysts, with very condensed DNA and being located at the posterior of the egg chamber. In the remaining 8-cell cysts, the DNA of the putative oocyte shows different degrees of polyploidisation and the cell often fails to reach the posterior of the egg chamber. The 16-cell cysts are mostly normal, although 2% fail to develop a normal oocyte.

(Mata et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, stg^UASp.cMa has cyst cell of ovary phenotype, suppressible by trbl^EPg35131/Scer\GAL4^{VP16.nanos.UTR}

(Mata et al., 2000)