FB2026_02 , released June 18, 2026
Allele: Dmel\p53R155H.UAS.Ex
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General Information
Symbol
Dmel\p53R155H.UAS.Ex
Species
D. melanogaster
Name
FlyBase ID
FBal0117414
Feature type
allele
Associated gene
Dmel\p53
Associated Insertion(s)
Carried in Construct
P{UAS-p53.R155H.Ex}
Key Links
Transgenic product class
missense_variant
(Ollmann et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ollmann et al., 2000)
Mutagen
in vitro construct
(Ollmann et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-p53.R155H.Ex}
Cytology
Description

Expression of p53 open reading frame is driven by the UAS regulatory sequences. The alpha tubulin 3' UTR provides stability to the message. Amino acid replacement: R155H.

(Ollmann et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
p53
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  ataxia telangiectasia
      modeled by tefuΔ356
      (Song et al., 2004)
      ameliorates  cancer
      modeled by Ptip3804, Ras85DV12.cUa.UAS
      (Dong et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of p53R155H.Scer\UAS.Ex under the control of Scer\GAL4Bx-MS1096 does not result in defects in the wing.

      (Merino et al., 2002)

      When expression is driven in the posterior compartment of the wing disc by Scer\GAL4en-e16E, X irradiation-induced apoptosis is blocked.

      (Ollmann et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4en-e16E/p53R155H.UAS.Ex is a suppressor of increased cell death phenotype of tefuΔ356

      (Song et al., 2004)
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4en-e16E/p53R155H.UAS.Ex is a suppressor of wing disc phenotype of tefuΔ356

      (Song et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      p53R155H.UAS.Ex/Scer\GAL4ey.PU is a non-suppressor of eye disc phenotype of Scer\GAL4ey.PU, vitoGD10890

      (Marinho et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of p53R155H.Scer\UAS.Ex in the Scer\GAL4ey.PU, vitoGD10890 background does not rescue the increased apoptosis phenotype or eye disc size.

      (Marinho et al., 2011)

      Expression of p53R155H.Scer\UAS.Ex under the control of Scer\GAL4en-e16E results in a substantial decrease in apoptosis (in the domain of Scer\GAL4en-e16E expression) in third larval instar tefuΔ356 wing discs (from Df(3R)Hsc70-4Δ356 animals in which the lack of Hsc70-4 function has been rescued by Hsc70-4+t14).

      (Song et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dmp53R155H
      (Merino et al., 2002)
      p53R155H.Scer\UAS.Ex
      p53R155H.UAS.Ex
      Name Synonyms
      Secondary FlyBase IDs
        References (6)