FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\apHA-B.UAS
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General Information
Symbol
Dmel\apHA-B.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0117606
Feature type
allele
Associated gene
Dmel\ap
Associated Insertion(s)
Carried in Construct
P{UAS-ap.HA/B}
Key Links
Transgenic product class
missense_variant
(Rincon-Limas et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rincon-Limas et al., 2000)
Mutagen
in vitro construct
(Rincon-Limas et al., 2000)
Progenitor genotype
apUAS.cRa
(Rincon-Limas et al., 2000)
Carried in construct
P{UAS-ap.HA/B}
Cytology
Description

Construct: Amino acid replacement: R3G. Nucleotide substitution: AGA?GGA Amino acid replacement: R5G. Nucleotide substitution: AGA?GGA Amino acid replacement: T6N. Nucleotide substitution: ACC?AAC Amino acid replacement: V47L. Nucleotide substitution: GTC?CTC Amino acid replacement: W48G. Nucleotide substitution: UGG?GGG Amino acid replacement: F49I. Amino acid replacement: Q50P. Nucleotide substitution: CAA?CCA Amino acid replacement: N51S. Nucleotide substitution: AAT?AGT Amino acid replacement: R53K. Nucleotide substitution: AGG?AAG The numbering of amino acids starts at the beginning of the homeodomain.

(Rincon-Limas et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ap
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of apHA-B.Scer\UAS when driven by Scer\GAL4ap-md544, causes abnormalities in the wing in a small percentage of flies. For example, wing blistering and pointed shaped wing can be observed. apmd544/apts78j flies grown at 25oC have wings that lack most of the wing margin but have good proximo-distal growth. The addition of apHA-B.Scer\UAS severely reduces proximo-distal growth and wing size.

      (Rincon-Limas et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      apHA-B.Scer\UAS
      apHA-B.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)