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General Information
Symbol
Dmel\apts78j
Species
D. melanogaster
Name
FlyBase ID
FBal0030507
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

apts78j/apmd544 flies show a nearly complete loss of wings at 25oC.

apmd544/apts78j flies grown at 25oC have wings that lack most of the wing margin but have good proximo-distal growth. The addition of apHA-B.Scer\UAS severely reduces proximo-distal growth and wing size.

apmd544/apts78j flies have defective wing margins and unfused wing surfaces at 18oC. Introduction of apΔHD.Scer\UAS into this background (expressed under the control of Scer\GAL4ap-md544) eliminates the wing blade altogether.

Homozygous apts78j flies were reared at the permissive temperature, 18oC, wings develop in a quasinormal way, and at the restrictive 25oC, temperature, wings fail to develop.

Temperature-sensitive mutation. Heterozygous or homozygous females show reduced levels of ornithine decarboxylase activity relative to wild-type at 29oC. Heterozygous females are vitellogenic and homozygous females are non-vitellogenic at 29oC.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Coexpression of mewScer\UAS.cWa and fngScer\UAS.cKa under the control of Scer\GAL4ap-md544 partially rescues the apts78j/apmd544 wing phenotype; the overall size and shape, apposition of the two surfaces, position of the wing margin and pattern of the wing veins are remarkably normal. However, these wings consist entirely of ventral cell types. Firstly, the rescued wing margins lack the dorsal-specific bristles types and instead have ventral bristle types on both surfaces. Secondly, the wings have many more alula bristles than normal (which in wild-type are derived only from the ventral surface). Thirdly, a mechanosensory campaniform sensillum that is normally located only on the ventral surface of vein L3 is duplicated and present on both surfaces of the rescued wing. Finally, the morphology of the wing veins indicate that they entirely of ventral identity (the veins show a ventral corrugation pattern on both surfaces of the wing).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
apts78j
Name Synonyms
Secondary FlyBase IDs
    References (5)