No mutations have been detected in the conv coding region.
Unlike wild-type, post stage 15 trachea in convk06507b homozygotes are unable to exclude from their lumens, a fluorescently labelled 10kDa dextran injected into the body cavity. This is consistent with these trachea lacking a functioning septate junction barrier.
Early tracheal development, including primary branch budding and outgrowth and lumen formation and morphology occur normally during stages 11-14. Stage 16 embryos show a number of tracheal defects. These include an increased length of the dorsal trunk compared to wild type (with no accompanying increase in cell number) and mild defects in the diameter of the dorsal trunk and other primary branches. Irregular and variable tracheal tube morphologies, with local constrictions and/or dilations are seen in all major branches. The defects are first seen at stage 15.
The tracheal defects of sinunwu7 mutant embryos are more severe in double mutant combination with convk06507b (severe diameter defects are seen in all multicellular branches and dorsal trunk length appears increased).
The tracheal phenotypes of nrv2nwu3 homozygotes are exacerbated by convk06507b/convk06507b.
Separable from: P{lacW}sopk06507a. The convk06507b mutation is separable from the sopk06507a mutation caused by the P{lacW}sopk06507a insertion.
