Open Close
General Information
Symbol
Dmel\convR278
Species
D. melanogaster
Name
FlyBase ID
FBal0230219
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C14272813T

Reported nucleotide change:

C?T

Amino acid change:

S469L | conv-PA; S469L | conv-PB

Reported amino acid change:

S469L

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: S469L.

Nucleotide substitution: C?T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous larvae hatch and begin crawling, but do not survive past the second larval instar.

100% of trachea in convY58/convR278 larvae fail to fill with air.

The trachea in mutant embryos appear normal through stage 15, but by stage 16 they become overly long and "convoluted".

Adherens junctions and septate junctions in the trachea appear ultrastructurally normal in stage 17 convR278/Df(2R)7131 embryos. At stage 16, the lumenal matrix of the trachea appears to be less dense and somewhat grainer than normal and some taenidial ridges are abnormal. By stage 17, the mutant lack the normal gap between the matrix and the lumen wall, and the taenidial defects are more pronounced.

Chitin accumulates normally in the tracheal lumen of convR278/convY58 stage 17 embryos. The gaps that normally appear between the lumenal walls the matrix are missing in these embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Additional Comments
Genetic Interactions
Statement
Reference

The tracheal tube length defects caused by convR278 are not enhanced if the embryos are also mutant for either dpOVLR or shgg119.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Rescued by
Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)