FlyBase Allele Report: Dmel\conv[Y58]

General Information

Symbol

Dmel\conv^Y58

Species

D. melanogaster

Name

FlyBase ID

FBal0230224

Feature type

allele

Associated gene

Dmel\conv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Swanson et al., 2009)

Progenitor genotype

P{lacW}Sps1^SH1599

(Swanson et al., 2009)

Caused by aberration

Df(2R)conv^Y58

Cytology

Description

Imprecise excision of the P{lacW}SelD^SH1599 insertion, resulting in a deficiency that removes the entire intergenic region 5' of conv as well as part of the conv transcription unit. The SelD gene is also disrupted.

(Swanson et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:14,269,308..14,271,458 [+]

Comment:

Deletion resulting from the imprecise excision of P{lacW}Sps1^SH1599 that affects both conv and Sps1.

(Swanson et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of second instar larval stage (with conv^R278)

(Swanson et al., 2009)

lethal - all die before end of second instar larval stage | recessive

(Swanson et al., 2009)

some die during second instar larval stage (with conv^R278)

(Swanson et al., 2009)

some die during second instar larval stage | recessive

(Swanson et al., 2009)

Phenotype Manifest In

larval tracheal system (with conv^R278)

(Swanson et al., 2009)

presumptive embryonic/larval tracheal system (with conv^R278)

(Swanson et al., 2009)

Detailed Description

Statement

Reference

Homozygous larvae hatch and begin crawling, but do not survive past the second larval instar.

100% of trachea in conv^Y58/conv^R278 larvae fail to fill with air.

conv^Y58/Df(2R)7131 embryos do not have paracellular barrier defects, as shown by wild-type-like impermeability of trachea and salivary glands to a 10kD dextran dye.

Chitin accumulates normally in the tracheal lumen of conv^R278/conv^Y58 stage 17 embryos. The gaps that normally appear between the lumenal walls the matrix are missing in these embryos.

(Swanson et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

conv^Y58 is rescued by conv^+t6

(Swanson et al., 2009)

Partially rescued by

conv^R278/conv^Y58 is partially rescued by conv^UAS.YFP/Scer\GAL4^btl.PS

(Swanson et al., 2009)

conv^R278/conv^Y58 is partially rescued by Scer\GAL4^btl.PS/conv^UAS.cSa

(Swanson et al., 2009)

Not rescued by

conv^Y58 is not rescued by conv^UAS.cSa/Scer\GAL4^ppl.PP

(Swanson et al., 2009)

conv^Y58 is not rescued by Scer\GAL4^Cg.PA/conv^UAS.cSa

(Swanson et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

conv^Y58

(Swanson et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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