FlyBase Allele Report: Dmel\Lar[unspecified]

General Information

Symbol

Dmel\Lar^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0118426

Feature type

allele

Associated gene

Dmel\Lar

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Astigarraga et al., 2010)

female sterile

(Astigarraga et al., 2010)

Phenotype Manifest In

medulla

(Astigarraga et al., 2010)

photoreceptor cell R7

(Astigarraga et al., 2010)

Detailed Description

Statement

Reference

The majority of R7 axons terminate prematurely in the same target layer in the medulla, M3, as R8 axons.

(Astigarraga et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Lar^unspecified has abnormal neuroanatomy phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Lar^unspecified has female sterile phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Other

Statement

Reference

Lar^unspecified, Liprin-β^Δ83 has abnormal neuroanatomy phenotype

(Astigarraga et al., 2010)

Lar^unspecified, Liprin-β^Δ51 has abnormal neuroanatomy phenotype

(Astigarraga et al., 2010)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Lar^unspecified has photoreceptor cell R7 phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Lar^unspecified has medulla phenotype, non-suppressible by Liprin-γ^H1/Liprin-γ^S1

(Astigarraga et al., 2010)

Other

Statement

Reference

Lar^unspecified, Liprin-β^Δ83 has photoreceptor cell R7 phenotype

(Astigarraga et al., 2010)

Lar^unspecified, Liprin-β^Δ83 has medulla phenotype

(Astigarraga et al., 2010)

Lar^unspecified, Liprin-β^Δ51 has photoreceptor cell R7 phenotype

(Astigarraga et al., 2010)

Lar^unspecified, Liprin-β^Δ51 has medulla phenotype

(Astigarraga et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

In Lar^unspecified, Liprin-β^Δ83 or Lar^unspecified, Liprin-β^Δ51 double mutants, many R7 axons terminate prematurely in the M3 layer of the medulla. However, a few R7 axons extend far beyond the boundary of the medulla.

(Astigarraga et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Lar²¹²⁷

(Maurel-Zaffran et al., 2001)

Lar^C105

(Maurel-Zaffran et al., 2001)

Lar^C12

(Maurel-Zaffran et al., 2001)