FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Ecol\lacZFMRFa.WF22
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General Information
Symbol
Ecol\lacZFMRFa.WF22
Species
E. coli
Name
FlyBase ID
FBal0118532
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
Carried in Construct
P{WF22}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Taghert et al., 2000)
Progenitor genotype
Ecol\lacZhs43
(Taghert et al., 2000)
Carried in construct
P{WF22}
Cytology
Description

Bases -418 to -162 of the upstream region of the FMRFa gene drives expression of lacZ. The enhancer fragment is in the opposite orientation to normal with respect to the heterologous promoter.

(Taghert et al., 2000)
Allele components
Component
Use(s)
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult ellipsoid body ring neuron R4d
      (Martín-Peña et al., 2014)
      adult ellipsoid body ring neuron R4m
      (Martín-Peña et al., 2014)
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      ellipsoid body | restricted
      (Renn et al., 1999)
      large field neuron | subset
      (Renn et al., 1999)
      adult ellipsoid body ring neuron R4 | distal | subset
      (Renn et al., 1999)
      bulb
      (Renn et al., 1999)
      adult mushroom body
      (Renn et al., 1999)
      Additional Information
      Statement
      Reference

      EcollacZFMRFa.WF22 drives expression in about 12 ring neurons R4d and R4m at 7-8 days of age.

      (Martín-Peña et al., 2014)

      Adult expression is observed large field neurons with cell bodies located on the anterior surface of the brain, that arborize in the lateral triangle and before the ellipsoid body.

      (Renn et al., 1999)
       
      Marker for
      adult ellipsoid body ring neuron R4d
      (Renn et al., 1999)
      ellipsoid body
      (Renn et al., 1999)
      Reflects expression of
      FMRFa
      (Martín-Peña et al., 2014)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ecol\lacZFMRFa.WF22
      Ecol\lacZFmrf.WF22
      Name Synonyms
      Secondary FlyBase IDs
        References (4)