FlyBase Allele Report: Dmel\mub[EP3623]

General Information

Symbol

Dmel\mub^EP3623

Species

D. melanogaster

Name

FlyBase ID

FBal0119178

Feature type

allele

Associated gene

Dmel\mub

Associated Insertion(s)

P{EP}mub^EP3623

Carried in Construct

Also Known As

EP(3)3623

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Levis, 2001.2.27, Lukacsovich et al., 2001, Fernandez-Funez et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}mub^EP3623

Cytology

Description

P{EP} insertion in a 5' exon.

(Levis, 2001.2.27)

The P{EP} insertion is inserted 22bp into the 5' non-coding exon, separated from thr initial ATG by about a 28kb intron. It is in the same orientation to the transcription unit.

(Fernandez-Funez et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:21,879,653..21,879,653 [+]

(Branco et al., 2008, Sofola et al., 2007, Gene Disruption Project members, 2001-, Levis, 2001.2.27, Lukacsovich et al., 2001, Fernandez-Funez et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Fernandez-Funez et al., 2000)

modeled by Hsap\ATXN1^30Q.UAS

(Fernandez-Funez et al., 2000)

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN7^{102Q.T.UAS.Tag:NLS(SV40-largeT)}

(Latouche et al., 2007)

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

No retinal phenotypes are seen when mub^EP3623 is expressed under the control of Scer\GAL4^GMR.PU.

No climbing defects are seen when mub^EP3623 is expressed under the control of Scer\GAL4^nrv2.PS.

(Branco et al., 2008)

Expression of mub^EP3623 under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype.

(Shulman and Feany, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mub^EP3623, Scer\GAL4^nrv2.PS is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

mub^EP3623, Scer\GAL4^{elav.Switch.PO} is an enhancer of short lived | RU486 conditional phenotype of Hsap\ATXN7^{102Q.T.UAS.Tag:NLS(SV40-largeT)}, Scer\GAL4^{elav.Switch.PO}

(Latouche et al., 2007)

NOT Enhancer of

Statement

Reference

mub^EP3623, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

mub^EP3623, Scer\GAL4^nrv2.PS is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Branco et al., 2008)

mub^EP3623, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

NOT Suppressor of

Statement

Reference

mub^EP3623, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

mub^EP3623, Scer\GAL4^GMR.PU is an enhancer of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

NOT Enhancer of

Statement

Reference

mub^EP3623, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

mub^EP3623, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

mub^EP3623, Scer\GAL4^GMR.PU is a suppressor of ommatidium phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

mub^EP3623, Scer\GAL4^GMR.PU is a suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

mub^EP3623, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

mub^EP3623, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Suppressor of

Statement

Reference

mub^EP3623, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of mub^EP3623 enhances the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of mub^EP3623 suppresses the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

Expression of mub^EP3623 partially suppresses the climbing defects seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS.

Expression of mub^EP3623 enhances the climbing defects seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^nrv2.PS.

(Branco et al., 2008)

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying mub^EP3623.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EP(3)3623

(Shulman and Feany, 2003, Levis, 2001.2.27, Lukacsovich et al., 2001)

mub^EP3623

(Latouche et al., 2007, Sofola et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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