FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cgY4
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General Information
Symbol
Dmel\cgY4
Species
D. melanogaster
Name
FlyBase ID
FBal0119300
Feature type
allele
Associated gene
Dmel\cg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Campbell and Tomlinson, 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: H90L.

(Campbell and Tomlinson, 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:14,178,422..14,178,422 [+]
Nucleotide change:

A14178422T

Amino acid change:

H253L | cg-PA; H354L | cg-PB; H211L | cg-PC; H253L | cg-PD; H346L | cg-PF; H354L | cg-PI; H354L | cg-PJ; H246L | cg-PK; H366L | cg-PL; H361L | cg-PM; H261L | cg-PN

Reported amino acid change:

H90L

Comment:

The cg annotation has been extended substantially at the 5' end since the @cg[Y4} mutation was reported accounting for the apparent discrepency in amino acid location between the publication and the annotation. The site of nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.

(Campbell and Tomlinson, 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show no overgrowth in leg discs. Heterozygotes show an increase in the number of sex comb teeth compared to wild type.

      (Campbell and Tomlinson, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      cgY4, en[+]/en59 has visible | dominant phenotype

      (Campbell and Tomlinson, 2000)

      cgY4, en59 has visible | dominant phenotype

      (Campbell and Tomlinson, 2000)
      Phenotype Manifest In
      Other
      Statement
      Reference

      cgY4, en[+]/en59 has wing vein L4 phenotype

      (Campbell and Tomlinson, 2000)

      cgY4, en59 has wing vein L4 phenotype

      (Campbell and Tomlinson, 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      cgY4 en59 double heterozygotes have a fully penetrant loss of wing vein L4 phenotype.

      (Campbell and Tomlinson, 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      cg07659

      (Campbell and Tomlinson, 2000)
      Partially rescued by

      cgY4 is partially rescued by cg+t11.5

      (Campbell and Tomlinson, 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Appears to be a dominant negative mutation.

      (Campbell and Tomlinson, 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cgY4
      Name Synonyms
      Secondary FlyBase IDs
        References (1)