FB2026_02 , released June 18, 2026
Allele: Dmel\cgA22
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General Information
Symbol
Dmel\cgA22
Species
D. melanogaster
Name
FlyBase ID
FBal0119301
Feature type
allele
Associated gene
Dmel\cg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    cgY4
    (Campbell and Tomlinson, 2000)
    Cytology
    Description

    Amino acid replacement: R107term.

    (Campbell and Tomlinson, 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    MNV
    2R:14,178,472..14,178,474 [+]
    Nucleotide change:

    CGC14178472TGA

    Amino acid change:

    R270term | cg-PA; R371term | cg-PB; R228term | cg-PC; R270term | cg-PD; R363term | cg-PF; R371term | cg-PI; R371term | cg-PJ; R263term | cg-PK; R383term | cg-PL; R378term | cg-PM; R278term | cg-PN

    Reported amino acid change:

    R107term

    Comment:

    The cg annotation has been extended substantially at the 5' end since the @cg[A22] mutation was reported accounting for the apparent discrepency in the amino acid location of the mutation between the publication and the FlyBase annotation. The reported amino acid change (from CGC to TAA, TGA, or TAG) requires substitution of at least the first and third nucleotides of the the codon. The site of nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change. It has been annotated as a TGA stop codon, though the identity of the stop codon was not reported.

    (Campbell and Tomlinson, 2000)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        en59 cgA22 double heterozygotes are indistinguishable from en59/+ flies with regard to wing vein L4.

        (Campbell and Tomlinson, 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        cgA22 is rescued by cg+t11.5

        (Campbell and Tomlinson, 2000)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Revertant of the dominant negativity of cgY4.

        (Campbell and Tomlinson, 2000)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        cgA22
        (Davis and Rebay, 2017)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)