FlyBase Allele Report: Dmel\mir-ban[EP3208]

General Information

Symbol

Dmel\mir-ban^EP3208

Species

D. melanogaster

Name

FlyBase ID

FBal0119632

Feature type

allele

Associated gene

Dmel\mir-ban

Associated Insertion(s)

P{EP}mir-ban^EP3208

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Hipfner et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}mir-ban^EP3208

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:637,528..637,528 [+]

(Bilen et al., 2006, Hipfner et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen et al., 2006)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

decreased body size (with Df(3L)mir-ban^Δ1)

(Hipfner et al., 2002)

female sterile (with Df(3L)mir-ban^Δ1)

(Hipfner et al., 2002)

viable (with Df(3L)mir-ban^Δ1)

(Hipfner et al., 2002)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

scutellar bristle | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

tormogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

wing, with Scer\GAL4^en-e16E

(Hipfner et al., 2002)

Detailed Description

Statement

Reference

The body mass of ban^EP3208/Df(3L)ban^Δ1 adults is only 89% of that of control flies. Expression of ban^EP3208 under the control of Scer\GAL4^en-e16E results in a significant increase in the ratio of posterior:anterior area of the wing compared to control wings. There is no increase in overall wing size.

(Hipfner et al., 2002)

Mutant larvae expressing ban^EP3208 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. Mutant larvae expressing ban^EP3208 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects.

(Kraut et al., 2001)

Expression of ban^EP3208 under the control of Scer\GAL4^sca-537.4 results in additional scutellar macrochaetae. Sensory organs with no socket and one shaft are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, mir-ban^EP3208 has visible phenotype, non-enhanceable by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, mir-ban^EP3208 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, mir-ban^EP3208 has visible phenotype, non-suppressible by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, mir-ban^EP3208 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

mir-ban^EP3208/Df(3L)mir-ban^Δ1 is an enhancer of increased cell death phenotype of Hsap\ATXN3^{tr.Q78.GMR.Tag:HA}

(Bilen et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

mir-ban^EP3208/Df(3L)mir-ban^Δ1 is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.GMR.Tag:HA}

(Bilen et al., 2006)

mir-ban^EP3208/Df(3L)mir-ban^Δ1 is an enhancer of retina phenotype of Hsap\ATXN3^{tr.Q78.GMR.Tag:HA}

(Bilen et al., 2006)

NOT Enhancer of

Statement

Reference

mir-ban^EP3208/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

mir-ban^EP3208/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

NOT Suppressor of

Statement

Reference

mir-ban^EP3208/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Reduction of ban activity through ban^EP3208/Df(3L)ban^Δ1 enhances Hsap\MJD^{tr.Q78.GMR.T:Ivir\HA1}-induced degeneration, such that flies are now born with more neuronal loss.

(Bilen et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: a lethal mutation at another locus on the chromosome.

(Hipfner et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EP(3)3208

(Abdelilah-Seyfried et al., 2000)

EP3208^EP3208

(Kraut et al., 2001)

ban^EP3208

mir-ban^EP3208

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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