FlyBase Allele Report: Dmel\rho[UAS.cUa]

General Information

Symbol

Dmel\rho^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0120373

Feature type

allele

Associated gene

Dmel\rho

Associated Insertion(s)

Carried in Construct

P{UAS-rho.U}

Also Known As

UAS-rho

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-rho.U}

Cytology

Description

UAS regulatory sequences govern expression of rho.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

rho

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | embryonic stage 15, with Scer\GAL4^prd.PU

(Wang et al., 2017)

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

(Zhang et al., 2019)

visible, with Scer\GAL4^Bx-MS1096

(Brentrup et al., 2000)

Phenotype Manifest In

adult midgut epithelium, with Scer\GAL4^esg.PU

(Zhang et al., 2019)

anterior crossvein, with Scer\GAL4^e22c

(Li et al., 2007)

embryonic/larval oenocyte | ectopic | embryonic stage 15, with Scer\GAL4^prd.PU

(Wang et al., 2017)

embryonic/larval oenocyte | embryonic stage 15, with Scer\GAL4^prd.PU

(Wang et al., 2017)

posterior crossvein, with Scer\GAL4^e22c

(Li et al., 2007)

wing, with Scer\GAL4^Bx-MS1096

(Brentrup et al., 2000)

wing vein L3, with Scer\GAL4^e22c

(Li et al., 2007)

wing vein L4, with Scer\GAL4^e22c

(Li et al., 2007)

Detailed Description

Statement

Reference

Adulthood-only expression of rho^UAS.cUa under the combined control of Scer\GAL4^esg.PU and Gal80[ts], induced by temperature shift to 29[o]C for 6 days during adulthood, leads to a significant increase in the number of mitotic cells (phospho-H3 staining) in the adult midgut, as compared to controls

(Zhang et al., 2019)

The expression of rho^Scer\UAS.cUa under the control of Scer\GAL4^prd.PU leads to extra and ectopic oenocytes in Prd-positive abdominal and thoracic segments, respectively, during stage 15 of embryogenesis, as compared to controls.

(Wang et al., 2017)

Expression of rho^Scer\UAS.cUa in the wing disc under the control of Scer\GAL4^e22c results in loss of partial posterior cross vein and anterior cross vein and weakened distal portion of L4 and L3-4 M veins.

(Li et al., 2007)

Expression of rho^Scer\UAS.cUa under the control of Scer\GAL4^dpp.blk1 does not induce ectopic furrow formation in the eye disc.

(Kumar and Moses, 2001)

Entire wing blade is composed of wing vein tissue of dorsal and ventral epithelia that fail to adhere.

(Brentrup et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^prd.PU, rho^UAS.cUa has increased cell number | embryonic stage 15 phenotype, enhanceable by abd-A^UAS.cGa/Scer\GAL4^prd.PU

(Wang et al., 2017)

Suppressed by

Statement

Reference

Scer\GAL4^esg.PU, rho^UAS.cUa has increased occurrence of cell division | adult stage phenotype, suppressible by Rab11^JF02812, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Scer\GAL4^prd.PU, rho^UAS.cUa has increased cell number | embryonic stage 15 phenotype, suppressible by hth^Meis1-P2/hth^Meis1-P2

(Wang et al., 2017)

Scer\GAL4^Bx-MS1096, rho^UAS.cUa has visible phenotype, suppressible by net^UAS.cBa/Scer\GAL4^Bx-MS1096

(Brentrup et al., 2000)

Enhancer of

Statement

Reference

Scer\GAL4^prd.PU/rho^UAS.cUa is an enhancer of increased cell number | embryonic stage 15 phenotype of Scer\GAL4^prd.PU, abd-A^UAS.cGa

(Wang et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^prd.PU/rho^UAS.cUa is a suppressor of decreased cell number | recessive | embryonic stage 15 phenotype of hth^Meis1-P2

(Wang et al., 2017)

Scer\GAL4^vn-GAL4/rho^UAS.cUa is a suppressor | partially of lethal - all die before end of pupal stage phenotype of vn^L6/vn^GAL4

(Austin et al., 2014)

Scer\GAL4^Bx-MS1096/rho^UAS.cUa is a suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, net^UAS.cBa

(Brentrup et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^prd.PU, rho^UAS.cUa has embryonic/larval oenocyte | embryonic stage 15 phenotype, enhanceable by abd-A^UAS.cGa/Scer\GAL4^prd.PU

(Wang et al., 2017)

Suppressed by

Statement

Reference

Scer\GAL4^esg.PU, rho^UAS.cUa has adult midgut epithelium phenotype, suppressible by Rab11^JF02812, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Scer\GAL4^prd.PU, rho^UAS.cUa has embryonic/larval oenocyte | embryonic stage 15 phenotype, suppressible by hth^Meis1-P2/hth^Meis1-P2

(Wang et al., 2017)

Scer\GAL4^Bx-MS1096, rho^UAS.cUa has wing phenotype, suppressible by net^UAS.cBa/Scer\GAL4^Bx-MS1096

(Brentrup et al., 2000)

Enhancer of

Statement

Reference

Scer\GAL4^prd.PU/rho^UAS.cUa is an enhancer of embryonic/larval oenocyte | embryonic stage 15 | ectopic phenotype of Scer\GAL4^prd.PU, abd-A^UAS.cGa

(Wang et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^prd.PU/rho^UAS.cUa is a suppressor of embryonic/larval oenocyte | embryonic stage 15 phenotype of hth^Meis1-P2

(Wang et al., 2017)

Scer\GAL4^vn-GAL4/rho^UAS.cUa is a suppressor of wing disc phenotype of vn^L6/vn^GAL4

(Austin et al., 2014)

Scer\GAL4^Bx-MS1096/rho^UAS.cUa is a suppressor of wing vein phenotype of Scer\GAL4^Bx-MS1096, net^UAS.cBa

(Brentrup et al., 2000)

Other

Statement

Reference

Scer\GAL4^vn-GAL4, rho^UAS.cUa, vn^L6/vn^GAL4 has wing vein | ectopic phenotype

(Austin et al., 2014)

Scer\GAL4^vn-GAL4, rho^UAS.cUa, vn^L6/vn^GAL4 has wing vein phenotype

(Austin et al., 2014)

S^UAS.cGa, Scer\GAL4^dpp.blk1, rho^UAS.cUa has eye disc morphogenetic furrow phenotype

(Kumar and Moses, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Stage 15 embryos that express rho^Scer\UAS.cUa under the control of Scer\GAL4^prd.PU in a hth^Meis1-P2 homozygous background neither exhibit the ectopic/increased oenocytes in Prd-positive segments observed upon the expression of rho^Scer\UAS.cUa alone nor exhibit the absence of oenocytes observed in hth^Meis1-P2 homozygotes, but display a decrease in the number of oenocytes as compared to wild-type controls).

The co-expression of rho^Scer\UAS.cUa and abd-A^Scer\UAS.cGa under the control of Scer\GAL4^prd.PU enhances the increased and/or ectopic oenocytes in Prd-positive segments during stage 15 of embryogenesis displayed in either single expression condition.

(Wang et al., 2017)

Expression of rho^Scer\UAS.cUa under the control of Scer\GAL4^vn.GAL4 partially suppresses the lethality seen in vn^L6/vn^GAL4 mutant flies. Approximately 50% of flies reach adulthood and have grossly normal wings, although the region between veins L3 and L4 is fused and some extra vein material is observed. The wing disc is of normal size and pattern.

(Austin et al., 2014)

Expression of S^Scer\UAS.cGa and rho^Scer\UAS.cUa under the control of Scer\GAL4^dpp.blk1 results in ectopic furrow initiation in the eye disc.

(Kumar and Moses, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Unknown

(Brentrup et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

rho^Scer\UAS.cUa

rho^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

(Brentrup et al., 2000)

Secondary FlyBase IDs

References (11)

Report Sections

Open Close