FlyBase Allele Report: Dmel\Lim1[UAS.cTb]

General Information

Symbol

Dmel\Lim1^UAS.cTb

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct b of Thomas

FlyBase ID

FBal0120774

Feature type

allele

Associated gene

Dmel\Lim1

Associated Insertion(s)

Carried in Construct

P{UAS-Lim1.Th}

Key Links

Transgenic product class

wild_type

(Pueyo et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Pueyo et al., 2000)

Mutagen

in vitro construct

(Pueyo et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Lim1.Th}

Cytology

Description

UAS governs expression of Lim1.

(Pueyo et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Lim1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

femur, with Scer\GAL4^dpp.blk1

(Pueyo and Couso, 2004)

metatarsus, with Scer\GAL4^dpp.blk1

(Pueyo and Couso, 2004)

tarsal segment 2, with Scer\GAL4^dpp.blk1

(Pueyo and Couso, 2004)

tarsal segment 3, with Scer\GAL4^dpp.blk1

(Pueyo and Couso, 2004)

tarsal segment 4, with Scer\GAL4^ap-md544

(Pueyo et al., 2000)

tarsal segment, with Scer\GAL4^30A

(Pueyo et al., 2000)

tarsal segment, with Scer\GAL4^ap-md544

(Pueyo and Couso, 2004)

tibia, with Scer\GAL4^dpp.blk1

(Pueyo and Couso, 2004)

unguis, with Scer\GAL4^dpp.blk1

(Pueyo and Couso, 2004)

Detailed Description

Statement

Reference

The legs of Lim1^Scer\UAS.cTb; Scer\GAL4^ap-md544 flies lack (some?) tarsal structures. In Lim1^Scer\UAS.cTb; Scer\GAL4^dpp.blk1 flies, the femur, tibia, and tarsal segments one to three are fused. In the pretarsus only one claw develops.

(Pueyo and Couso, 2004)

When expression is driven by Scer\GAL4^ap-md544 tarsus 4 is lost. When expression is driven by Scer\GAL4^30A mild tarsal segment fusions occur.

(Pueyo et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Lim1^UAS.cTb, Scer\GAL4^30A has tarsal segment phenotype, enhanceable by al^UAS.cSa, Scer\GAL4^30A

(Pueyo et al., 2000)

NOT Enhanced by

Statement

Reference

Lim1^UAS.cTb, Scer\GAL4^30A has tarsal segment phenotype, non-enhanceable by ap^unspecified, Scer\GAL4^30A

(Pueyo et al., 2000)

Suppressed by

Statement

Reference

Lim1^UAS.cTb, Scer\GAL4^ap-md544 has tarsal segment phenotype, suppressible | partially by Bar^UAS.cKa, Scer\GAL4^ap-md544

(Pueyo and Couso, 2004)

NOT suppressed by

Statement

Reference

Lim1^UAS.cTb, Scer\GAL4^30A has tarsal segment phenotype, non-suppressible by Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^30A

(Pueyo et al., 2000)

Lim1^UAS.cTb, Scer\GAL4^ap-md544 has tarsal segment 4 phenotype, non-suppressible by ap^UAS.cBa, Scer\GAL4^ap-md544

(Pueyo et al., 2000)

Enhancer of

Statement

Reference

Lim1^UAS.cTb, Scer\GAL4^30A is an enhancer of tarsal segment phenotype of Scer\GAL4^30A, al^UAS.cSa

(Pueyo et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of tarsal structures in Lim1^Scer\UAS.cTb; Scer\GAL4^ap-md544 flies is partially suppressed by B^Scer\UAS.cKa.

(Pueyo and Couso, 2004)

The combination of Lim1^Scer\UAS.cTb and al^Scer\UAS.cSa driven by Scer\GAL4^30A causes stronger tarsal fusion than either Lim1^Scer\UAS.cTb or al^Scer\UAS.cSa alone and loss of the joint between tarsal segments 4 and 5.

(Pueyo et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Lim1^Scer\UAS.cTb

Lim1^UAS.cTb

Name Synonyms

Saccharomyces cerevisiae UAS construct b of Thomas

(Pueyo et al., 2000)

Secondary FlyBase IDs

References (3)

Report Sections

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