FlyBase Allele Report: Dmel\Chi[FL.UAS.Tag:MYC]

General Information

Symbol

Dmel\Chi^{FL.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0103084

Feature type

allele

Associated gene

Dmel\Chi

Associated Insertion(s)

Carried in Construct

P{UAS-Chi.FL}

Also Known As

UAS-ChipFL, UAS-Chip

Key Links

Transgenic product class

wild_type

(van Meyel et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(van Meyel et al., 1999)

Mutagen

in vitro construct

(van Meyel et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-Chi.FL}

Cytology

Description

Full length Chi, tagged at the C-terminal end with 5 copies of Tag:MYC, is expressed under the control of UAS regulatory sequences.

(van Meyel et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Chi

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(van Meyel et al., 1999)

visible, with Scer\GAL4^Bx-MS1096

(Zenvirt et al., 2008)

visible | adult stage, with Scer\GAL4^pnr-MD237

(Zenvirt et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Scer\GAL4^αTub84B.PL>Chi^{FL.Scer\UAS.T:Hsap\MYC} completely prevents ectopic photoreceptor differentiation within Chi^45F mutant clones, although it has no effect when expressed in wild-type eye discs.

(Roignant et al., 2010)

Expression of Chi^{FL.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^pnr-MD237 causes lack of dorsocentral bristles compared to controls and a thoracic cleft. Expression under the control of Scer\GAL4^Bx-MS1096 results in lack of either one or two bristles from the anterior pair of dorsocentral bristles.

(Zenvirt et al., 2008)

In the legs of Chi^{FL.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^Dll-md23 flies, tarsal segments four and five are fused, and no claw (unguis) develops.

(Pueyo and Couso, 2004)

When Chi^{FL.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^ap-md544, adults have wings that are small, unfused with a poorly demarcated margin.

(van Meyel et al., 2003)

Flies expressing Chi^{FL.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ap-md544 show wing defects. The wings are small and lack regular structure and the wing margin is poorly demarcated.

(van Meyel et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^ap-md544 has visible phenotype, suppressible by ap^UAS.cOa, Scer\GAL4^ap-md544

(van Meyel et al., 1999)

Suppressor of

Statement

Reference

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^CCAP.PP is a suppressor of abnormal eclosion phenotype of Bx^EP1306, Scer\GAL4^CCAP.PP

(Hari et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^ap-md544 has wing phenotype, enhanceable by Ssdp^L7/Ssdp[+], Scer\GAL4^ap-md544

(van Meyel et al., 2003)

Suppressed by

Statement

Reference

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^ap-md544 has wing phenotype, suppressible by ap^UAS.cOa, Scer\GAL4^ap-md544

(van Meyel et al., 1999)

Suppressor of

Statement

Reference

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^CCAP.PP is a suppressor of wing phenotype of Bx^EP1306, Scer\GAL4^CCAP.PP

(Hari et al., 2008)

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^ap-md544 is a suppressor of tarsal segment 4 phenotype of Bar^UAS.cKa, Scer\GAL4^ap-md544

(Pueyo and Couso, 2004)

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^ap-md544 is a suppressor | partially of tarsal segment 4 phenotype of Bx^UAS.cZa, Scer\GAL4^ap-md544

(Pueyo and Couso, 2004)

NOT Suppressor of

Statement

Reference

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^ap-md544 is a non-suppressor of tarsal segment 4 phenotype of Scer\GAL4^ap-md544, tup^UAS.cTa

(Pueyo and Couso, 2004)

Chi^{FL.UAS.Tag:MYC}/Scer\GAL4^30A is a non-suppressor of pretarsus phenotype of ap^md544/ap^UGO35

(Pueyo et al., 2000)

Chi^{FL.UAS.Tag:MYC}/Scer\GAL4^30A is a non-suppressor of tarsal segment 4 phenotype of ap^md544/ap^UGO35

(Pueyo et al., 2000)

Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^30A is a non-suppressor of tarsal segment phenotype of Lim1^UAS.cTb, Scer\GAL4^30A

(Pueyo et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Chi^{FL.Scer\UAS.T:Hsap\MYC} with Bx^EP1306, both under the control of Scer\GAL4^Ccap.PP, suppresses the wing expansion defect found upon expression of Bx^EP1306 alone.

(Hari et al., 2008)

Loss of the fourth tarsal segment in the legs of Bx^Scer\UAS.cZa; Scer\GAL4^ap-md544 flies is partially suppressed by Chi^{FL.Scer\UAS.T:Hsap\MYC}. The loss of tarsal segment 4 in the legs of tup^Scer\UAS.cTa; Scer\GAL4^ap-md544 flies is not suppressed by ap^Scer\UAS.cOa or Chi^{FL.Scer\UAS.T:Hsap\MYC}. The loss of tarsal segment 4 in the legs of B^Scer\UAS.cKa; Scer\GAL4^ap-md544 flies is suppressed by Chi^{FL.Scer\UAS.T:Hsap\MYC}.

(Pueyo and Couso, 2004)

The addition of Ssdp^L7 dominantly enhances the wing defects seen in Scer\GAL4^ap-md544, Scer\GAL4^ap-md544 mutants, leaving little or no organised wing tissue.

(van Meyel et al., 2003)

The wing phenotype of flies expressing Chi^{FL.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ap-md544 is suppressed by co-expression of ap^Scer\UAS.cOa.

(van Meyel et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Chi^{FL.UAS.Tag:MYC}/Scer\GAL4^αTub84B.PL rescues Chi^45F

(Roignant et al., 2010)

Chi^{FL.UAS.Tag:MYC}/Scer\GAL4^ap-md544 rescues Chi^e5.5

(van Meyel et al., 2000)

Comments

Expression of Scer\GAL4^αTub84B.PL>Chi^{FL.Scer\UAS.T:Hsap\MYC} completely prevents ectopic photoreceptor differentiation within Chi^45F mutant clones.

(Roignant et al., 2010)

Chi^{FL.Scer\UAS.T:Hsap\MYC} rescues the interneuron pathfinding errors seen in Chi^e5.5 embryos when expressed under the control of Scer\GAL4^ap-md544.

(van Meyel et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Chi^{FL.Scer\UAS.T:Hsap\MYC}

Chi^{FL.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (8)

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