FB2026_02 , released June 18, 2026
Allele: Dmel\prd+mXa
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General Information
Symbol
Dmel\prd+mXa
Species
D. melanogaster
Name
FlyBase ID
FBal0121597
Feature type
allele
Associated gene
Dmel\prd
Associated Insertion(s)
Carried in Construct
P{prd+mXa}
Also Known As
prd-Prd
Key Links
Transgenic product class
inframe_deletion
(Xue et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Xue et al., 2001)
Mutagen
in vitro construct
(Xue et al., 2001)
Progenitor genotype
prd+t18
(Xue et al., 2001)
Carried in construct
P{prd+mXa}
Cytology
Description

Deletion of the intron sequences present in prd+t18.

(Xue et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
prd
Encoded product / tool
prd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      prd+mXa rescues Df(2L)Prl/prd4

      (Xue et al., 2001)

      prd+mXa rescues prd4

      (Xue et al., 2001)
      Partially rescues

      prd+mXa partially rescues Df(2L)Prl/prd4

      (Li et al., 2015)
      Comments

      prdΔPBC or prd+mXa rescues the larval pair rule phenotype and embryonic lethality seen in prd4/Df(2L)Prl animals; however rescue with prdΔPBC leads to a distorted segmentation phenotype in adult cuticles. prdΔPBC rescues accessory gland development and male fertility (not fully) to a similar extent as prd+mXa in prd4/Df(2L)Prl; however rescue with prdΔPBC leads to significantly reduced fecundity (fewer progeny) compared to rescue with prd+mXa. prdwt fails to rescue accessory gland development in prd4/Df(2L)Prl males. prd4/Df(2L)Prl males rescued with prdΔPBC show lower mating success compared to those rescued with prd+mXa, though they show no significant difference in climbing ability. Females mated to prd4/Df(2L)Prl males rescued with prdΔPBC (even two copies) behave like virgins, with low egg-laying, high receptivity and low rejection; mutant males rescued with prd+mXa behave similar to controls.

      (Li et al., 2015)

      One copy of prd+mXa fully rescues the cuticle phenotype of prd4 homozygous embryos. One copy of prd+mXa fully rescues prd4/Df(2L)Prl animals to adulthood. One copy of prd+mXa fully rescues the fertility of prd4/Df(2L)Prl males.

      (Xue et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      prd+mXa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)