FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\enok2
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General Information
Symbol
Dmel\enok2
Species
D. melanogaster
Name
FlyBase ID
FBal0121784
Feature type
allele
Associated gene
Dmel\enok
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Scott et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: C?Y. The mutation is a conserved residue in the zinc finger motif.

(Scott et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,102,236..24,102,236 [+]
Nucleotide change:

G24102236A

Amino acid change:

C746Y | enok-PA; C746Y | enok-PB

Reported amino acid change:

C?Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Scott et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      DOES NOT exacerbate  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Bodai et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Marked enok2 mutant female germline stem cells (GSCs) are present only 2 days after clone induction (ACI), but absent at 21 days ACI. Control clones are present at 21 days ACI. The mutant cells differentiate into marked mutant cysts. The cells in the mutant clones do not display signs of apoptosis.

      Tracing of homozygous enok2 mutant cap cells in mosaic germaria for 21 days after eclosion reveals that the proportion of mutant clones drops dramatically over the time course, while the percentage the control ones remains steady.

      (Xin et al., 2013)

      Homozygotes tend to enter the wandering third instar larval stage at about 7 days after larval hatching (ALH) at 25oC while their heterozygous counterparts take only 3.5 to 4.0 days. Approximately half of the animals die before pupariation formation. Those that pupate do so at around 10 days ALH. Homozygotes never eclose as adults. Homozygous mutant clones exhibit defects in the mushroom body. Mushroom bodies contain only what appears to be a γ lobe and have a reduced cell number.

      (Scott et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      enok[+]/enok2 is an enhancer of homeotic | adult stage phenotype of trx1

      (Umer et al., 2019)

      enok[+]/enok2 is an enhancer of homeotic | adult stage phenotype of trxE2

      (Umer et al., 2019)
      NOT Enhancer of
      Statement
      Reference

      enok[+]/enok2 is a non-enhancer of partially lethal - majority die phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4elav-C155

      (Bodai et al., 2012)
      Suppressor of
      Statement
      Reference

      enok[+]/enok2 is a suppressor of homeotic | adult stage phenotype of Pc1

      (Umer et al., 2019)

      enok[+]/enok2 is a suppressor of homeotic | adult stage phenotype of Pc11

      (Umer et al., 2019)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      enok[+]/enok2 is an enhancer of adult abdominal segment 5 phenotype of trx1

      (Umer et al., 2019)

      enok[+]/enok2 is an enhancer of adult abdominal segment 4 phenotype of trx1

      (Umer et al., 2019)

      enok[+]/enok2 is an enhancer of adult abdominal segment 5 phenotype of trxE2

      (Umer et al., 2019)

      enok[+]/enok2 is an enhancer of adult abdominal segment 4 phenotype of trxE2

      (Umer et al., 2019)
      Suppressor of
      Statement
      Reference

      enok[+]/enok2 is a suppressor of sex comb | ectopic phenotype of Pc1

      (Umer et al., 2019)

      enok[+]/enok2 is a suppressor of sex comb | ectopic phenotype of Pc11

      (Umer et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of enok2 does not enhance the reduction in eclosion rate seen when Hsap\HTTQ93.ex1p.Scer\UAS is expressed under the control of Scer\GAL4elav-C155.

      (Bodai et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Enok2
      (Kim et al., 2023)
      enok2
      (Umer et al., 2019, Xin et al., 2013, Bodai et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)