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General Information
Symbol
Dmel\enok2
Species
D. melanogaster
Name
FlyBase ID
FBal0121784
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G24102236A

Amino acid change:

C746Y | enok-PA; C746Y | enok-PB

Reported amino acid change:

C?Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: C?Y. The mutation is a conserved residue in the zinc finger motif.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Marked enok2 mutant female germline stem cells (GSCs) are present only 2 days after clone induction (ACI), but absent at 21 days ACI. Control clones are present at 21 days ACI. The mutant cells differentiate into marked mutant cysts. The cells in the mutant clones do not display signs of apoptosis.

Tracing of homozygous enok2 mutant cap cells in mosaic germaria for 21 days after eclosion reveals that the proportion of mutant clones drops dramatically over the time course, while the percentage the control ones remains steady.

Homozygotes tend to enter the wandering third instar larval stage at about 7 days after larval hatching (ALH) at 25oC while their heterozygous counterparts take only 3.5 to 4.0 days. Approximately half of the animals die before pupariation formation. Those that pupate do so at around 10 days ALH. Homozygotes never eclose as adults. Homozygous mutant clones exhibit defects in the mushroom body. Mushroom bodies contain only what appears to be a γ lobe and have a reduced cell number.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

enok[+]/enok2 is an enhancer of homeotic | adult stage phenotype of trx1

enok[+]/enok2 is an enhancer of homeotic | adult stage phenotype of trxE2

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

enok[+]/enok2 is a suppressor | partially of homeotic | adult stage phenotype of Pc11

enok[+]/enok2 is a suppressor | partially of homeotic | adult stage phenotype of Pc1

Phenotype Manifest In
Enhancer of
Statement
Reference

enok[+]/enok2 is an enhancer of adult abdominal segment 5 phenotype of trx1

enok[+]/enok2 is an enhancer of adult abdominal segment 4 phenotype of trx1

enok[+]/enok2 is an enhancer of adult abdominal segment 5 phenotype of trxE2

enok[+]/enok2 is an enhancer of adult abdominal segment 4 phenotype of trxE2

Suppressor of
Statement
Reference

enok[+]/enok2 is a suppressor | partially of sex comb | ectopic phenotype of Pc11

enok[+]/enok2 is a suppressor | partially of sex comb | ectopic phenotype of Pc1

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

One copy of enok2 does not enhance the reduction in eclosion rate seen when Hsap\HTTQ93.ex1p.Scer\UAS is expressed under the control of Scer\GAL4elav-C155.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)