FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\drlK371A.UAS
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General Information
Symbol
Dmel\drlK371A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0121800
Feature type
allele
Associated gene
Dmel\drl
Associated Insertion(s)
Carried in Construct
P{UAS-drl.K371A}
Key Links
Transgenic product class
missense_variant
(Yoshikawa et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yoshikawa et al., 2001)
Mutagen
in vitro construct
(Yoshikawa et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-drl.K371A}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of drl which is predicted to be catalytically inactive (carries the amino acid replacement K371A).

(Yoshikawa et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
drl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-neural expression of drlK371A.Scer\UAS, under the control of Scer\GAL4elav-C155 induces the partial or complete loss of adult mushroom body orthogonal lobes. This is the same phenotype as observed when Scer\GAL4elav-C155 is used to drive expression of drlScer\UAS.cCa.

      (Taillebourg et al., 2005)

      Expression of three copies of drlK371A.Scer\UAS under the control of Scer\GAL4eg-Mz360 results in eg-expressing posterior commissure axons switching their projections and crossing the midline in the anterior commissure, in 96% of segments.

      (Yoshikawa et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4elav-C155/drlK371A.UAS partially rescues drl2/drlR343

      (Taillebourg et al., 2005)
      Comments

      Expression of drlK371A.Scer\UAS, under the control of Scer\GAL4elav-C155 can completely rescue the mushroom body phenotype of drl2/drlR343 in 30% of cases.

      (Taillebourg et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      drlK371A.Scer\UAS
      drlK371A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)