FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\svrEP356
Open Close
General Information
Symbol
Dmel\svrEP356
Species
D. melanogaster
Name
FlyBase ID
FBal0123682
Feature type
allele
Associated gene
Dmel\svr
Associated Insertion(s)
P{EP}svrEP356
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Pena-Rangel et al., 2002, Bayraktaroglu, 2001.6.13, Benos et al., 2001, Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}svrEP356
Cytology
Description

P{EP} falls within the 5' UTR of svr.

(Bayraktaroglu, 2001.6.13)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Cao et al., 2008)
      ameliorates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Cao et al., 2008)
      exacerbates  Alzheimer's disease
      modeled by Hsap\APPAβ42.GMR.Tag:SS(rPENK)
      (Cao et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression using Scer\GAL4ey.PU does not induce a rough eye phenotype.

      (Cao et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      svrEP356/Scer\GAL4pnr-MD237 is a suppressor of visible phenotype of pnrMD237

      (Pena-Rangel et al., 2002)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      svrEP356/Scer\GAL4ey.PU is an enhancer of eye phenotype of Hsap\APPAβ42.GMR.Tag:SS(rPENK)

      (Cao et al., 2008)
      Suppressor of
      Statement
      Reference

      svrEP356, Scer\GAL4ey.PU is a suppressor of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4ey.PU

      (Cao et al., 2008)

      svrEP356, Scer\GAL4GMR.PU is a suppressor of eye phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4GMR.PU

      (Cao et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

      (Pena-Rangel et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      svrEP356
      Name Synonyms
      Secondary FlyBase IDs
        References (5)