FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\comt3-13-3
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General Information
Symbol
Dmel\comt3-13-3
Species
D. melanogaster
Name
FlyBase ID
FBal0123923
Feature type
allele
Associated gene
Dmel\comt
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: E606K.

    (Golby et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:13,261,293..13,261,293 [+]
    Nucleotide change:

    G13261293A

    Amino acid change:

    E606K | comt-PA; E606K | comt-PB

    Reported amino acid change:

    E606K

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Golby et al., 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        When dissected from the pupal case the flies appear normal but are incapable of coordinated movement. The lethal phase is not altered in embryos derived from germ-line clones for comt3-13-3. Hemizygous male larvae take much longer than wild type to roll from lying on their dorsal surface to their ventral surface. They are often found protruding vertically from the surface of the medium for long periods of time and burrow deeply and die - possibly as a result of suffocation. Hemizygous males also accumulate gas in their intestinal tract.

        (Golby et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        comt3-13-3 has lethal | recessive | pharate adult stage phenotype, suppressible by Scer\GAL4elav-C155/Nsf2UAS.cGa

        (Golby et al., 2001)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        S. Titus and B. Ganetzky

        (Golby et al., 2001)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        comt3-13-3
        dNSF13-13-3
        (Golby et al., 2001)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)