FlyBase Allele Report: Dmel\comt[UAS.cGa]

General Information

Symbol

Dmel\comt^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Golby

FlyBase ID

FBal0123922

Feature type

allele

Associated gene

Dmel\comt

Associated Insertion(s)

Carried in Construct

P{UAS-comt.G}

Also Known As

UAS-dNsf1

Key Links

Transgenic product class

cDNA

(Golby et al., 2001)

wild_type

(Golby et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Golby et al., 2001)

wild_type

(Golby et al., 2001)

Mutagen

in vitro construct

(Golby et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-comt.G}

Cytology

Description

Expression of full length comt cDNA is governed by UASt regulatory sequences.

(Golby et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

comt

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

comt^UAS.cGa, Scer\GAL4^ple.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\SNCA^UAS.cUa, Scer\GAL4^ple.PU

(Babcock et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^how-24B/comt^UAS.cGa is a non-suppressor of lethal | recessive | larval stage phenotype of Nsf2¹⁵

(Golby et al., 2001)

Scer\GAL4^how-24B/comt^UAS.cGa is a non-suppressor of lethal | recessive | larval stage phenotype of Nsf2¹⁰³

(Golby et al., 2001)

Scer\GAL4^how-24B/comt^UAS.cGa is a non-suppressor of lethal | recessive | larval stage phenotype of Nsf2⁵⁵

(Golby et al., 2001)

Phenotype Manifest In

Suppressor of

Statement

Reference

comt^UAS.cGa, Scer\GAL4^ple.PU is a suppressor of dopaminergic PPL1 neuron phenotype of Hsap\SNCA^UAS.cUa, Scer\GAL4^ple.PU

(Babcock et al., 2015)

comt^UAS.cGa, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of αSnap^UAS.cPa, Scer\GAL4^GMR.PF

(Babcock et al., 2004)

comt^UAS.cGa, Scer\GAL4^elav-C155 is a suppressor of wing phenotype of αSnap^UAS.cPa, Scer\GAL4^elav-C155

(Babcock et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of comt^Scer\UAS.cGa with Snap^Scer\UAS.cPa under the control of Scer\GAL4^GMR.PF suppresses the eye phenotypes of the weaker P{UAS-Snap.P}1 insertion and partially suppresses the eye ablation phenotype of the stronger P{UAS-Snap.P}5 insertion. Furthermore, coexpression of comt^Scer\UAS.cGa under the control of Scer\GAL4^elav-C155 completely suppresses the wing inflation defect of Scer\GAL4^elav-C155>Snap^Scer\UAS.cPa flies.

(Babcock et al., 2004)

Xenogenetic Interactions

Statement

Reference

Co-expression of comt^Scer\UAS.cGa rescues the PPL1 dopaminergic neuron loss phenotype of flies expressing Hsap\SNCA^Scer\UAS.cUa under the control of Scer\GAL4^ple.PU.

(Babcock et al., 2015)

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/comt^UAS.cGa rescues comt^3-13-3

(Golby et al., 2001)

Scer\GAL4^elav-C155/comt^UAS.cGa rescues comt^clp

(Golby et al., 2001)

Partially rescues

Scer\GAL4^elav-C155/comt^UAS.cGa partially rescues comt⁴

(Golby et al., 2001)

Scer\GAL4^elav-C155/comt^UAS.cGa partially rescues comt⁶

(Golby et al., 2001)