FlyBase Allele Report: Dmel\Nsf2[15]

General Information

Symbol

Dmel\Nsf2¹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0124109

Feature type

allele

Associated gene

Dmel\Nsf2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Golby et al., 2001)

Mutagen

ethyl methanesulfonate

(Golby et al., 2001)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q294term.

(Golby et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:13,836,298..13,836,298 [-]

Nucleotide change:

C13836298T

Amino acid change:

Q294term | Nsf2-PA; Q294term | Nsf2-PB; Q294term | Nsf2-PC

Reported amino acid change:

Q294term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Golby et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Golby et al., 2001)

some die during larval stage | recessive

(Golby et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygotes have apparently normal embryogenesis and hatch, but die as larvae at the mid-first instar.

(Golby et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nsf2¹⁵ has lethal | recessive | larval stage phenotype, suppressible by comt^hs.PP

(Golby et al., 2001)

NOT suppressed by

Statement

Reference

Nsf2¹⁵ has lethal | recessive | larval stage phenotype, non-suppressible by Scer\GAL4^how-24B/comt^UAS.cGa

(Golby et al., 2001)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Nsf2²¹

(Golby et al., 2001)

Fails to complement

Nsf2¹⁰²

(Golby et al., 2001)

Nsf2¹⁰³

(Golby et al., 2001)

Nsf2¹¹

(Golby et al., 2001)

Nsf2⁴²

(Golby et al., 2001)

Nsf2⁵⁵

(Golby et al., 2001)

Nsf2⁶⁶

(Golby et al., 2001)

Rescued by

Nsf2¹⁵ is rescued by Nsf2^hs.PG

(Golby et al., 2001)

Nsf2¹⁵ is rescued by Nsf2^UAS.cGa/Scer\GAL4^C57

(Golby et al., 2001)

Nsf2¹⁵ is rescued by Nsf2^UAS.cGa/Scer\GAL4^Mef2.PR

(Golby et al., 2001)

Nsf2¹⁵ is rescued by Scer\GAL4^elav-C155/Nsf2^UAS.cGa/Scer\GAL4^how-24B

(Golby et al., 2001)

Partially rescued by

Nsf2¹⁵ is partially rescued by Nsf2^UAS.cGa/Scer\GAL4^how-24B

(Golby et al., 2001)

Not rescued by

Nsf2¹⁵ is not rescued by Scer\GAL4^elav-C155/Nsf2^UAS.cGa

(Golby et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Nsf2¹⁵

dNSF2¹⁵

(Golby et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (1)

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