FlyBase Allele Report: Dmel\Nsf2[55]

General Information

Symbol

Dmel\Nsf2⁵⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0124106

Feature type

allele

Associated gene

Dmel\Nsf2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Golby et al., 2001)

Mutagen

ethyl methanesulfonate

(Golby et al., 2001)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q130term.

(Golby et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:13,837,425..13,837,425 [-]

Nucleotide change:

C13837425T

Amino acid change:

Q130term | Nsf2-PA; Q130term | Nsf2-PB; Q130term | Nsf2-PC

Reported amino acid change:

Q130term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Golby et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | germline clone | larval stage | recessive

(Golby et al., 2001)

lethal | larval stage | recessive

(Golby et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygotes have apparently normal embryogenesis and hatch, but die as larvae at the mid-first instar. This lethal phase is not altered in embryos derived from germ-line clones for Nsf2⁵⁵.

(Golby et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nsf2⁵⁵ has lethal | recessive | larval stage phenotype, suppressible by comt^hs.PP

(Golby et al., 2001)

NOT suppressed by

Statement

Reference

Nsf2⁵⁵ has lethal | recessive | larval stage phenotype, non-suppressible by Scer\GAL4^how-24B/comt^UAS.cGa

(Golby et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

Nsf2⁵⁵ is an enhancer of eye phenotype of αSnap^UAS.cPa, Scer\GAL4^GMR.PF

(Babcock et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Snap^Scer\UAS.cPa from the P{UAS-Snap.P}1 in a Nsf2⁵⁵ background results in an enhancement of the Snap^Scer\UAS.cPa phenotype in the eye, including increased necrosis around the perimeter of the compound eye and more dramatic furrowing at ommatidial junctions.

(Babcock et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Nsf2²¹

(Golby et al., 2001)

Fails to complement

Nsf2¹⁰²

(Golby et al., 2001)

Nsf2¹⁰³