FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tsc1unspecified
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General Information
Symbol
Dmel\Tsc1unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0123959
Feature type
allele
Associated gene
Dmel\Tsc1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant cells in third instar eye-imaginal discs are larger than adjacent wild-type cells. Their nuclei are larger than wild type and have a more diffuse DNA staining pattern than normal. This difference in size is even more evident in the pupal retina where the mutant cells have clearly outgrown wild-type cells. The first and second mitotic waves occur normally in mutant clones. S phases occur normally in the asynchronously dividing cells anterior to the morphogenetic furrow as well as in cells undergoing the second mitotic wave in mutant tissue in the eye disc. However, ectopic S phases and mitoses occur posterior to the second mitotic wave in mutant clones.

        (Tapon et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhancer of
        Statement
        Reference

        Tsc1[+]/Tsc1unspecified is a non-enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Suppressor of
        Statement
        Reference

        Tsc1[+]/Tsc1unspecified is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4unspecified, hpoUAS.cUa

        (Udan et al., 2003)

        Tsc1[+]/Tsc1unspecified is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4cv-c-C5, hpoUAS.cUa

        (Udan et al., 2003)
        NOT Suppressor of
        Statement
        Reference

        Tsc1[+]/Tsc1unspecified is a non-suppressor of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        Tsc1[+]/Tsc1unspecified is a non-enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        Tsc1[+]/Tsc1unspecified is a non-suppressor of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Ras85DΔC40B Tsc1unspecified double mutant clones in the eye discs are no larger than Ras85DΔC40B single mutant clones.

        (Tseng et al., 2007)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Tsc1unspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (6)