FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Su(var)205G4DBD.hs
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General Information
Symbol
Dmel\Su(var)205G4DBD.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0123986
Feature type
allele
Associated gene
Dmel\Su(var)205
Associated Insertion(s)
Carried in Construct
P{hs-GAL4-HP1}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Seum et al., 2001)
Progenitor genotype
Carried in construct
P{hs-GAL4-HP1}
Cytology
Description

An almost full length copy of Su(var)205 (the first 10 N terminus amino acids are missing) are fused in frame to DNA binding domain of Scer\GAL4. This fusion protein is driven by heatshock promoter.

(Seum et al., 2000)
Allele components
Component
Use(s)
Encoded product / tool
Su(var)205
Tagged with
GAL4(DBD)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heat shock induction of one Su(var)205hs.T:Scer\GAL4 transgene results in variegation in P{Winkelried}A7 eyes. Variegation is not seen after Su(var)205hs.T:Scer\GAL4 induction in P{Winkelried(-FRT)}A7 eyes (P{Winkelried(-FRT)}A7 is the same as P{Winkelried}A7 but without Scer\GAL4-binding sites). Furthermore, variegation is not seen in P{Winkelried}A7, P{Winkelried(-FRT)}A7 eyes. Heat-shock induced expression of Su(var)205hs.T:Scer\GAL4, induces loops between the P{Winkelried}A7 insertion site and intercalary, pericentric or telomeric heterochromatin in polytene chromosomes. This effect is not seen with the P{Winkelried}D insertion.

      (Seum et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Eye colour: flies carrying both wScer\FRT.d1.Scer\UAS and Su(var)205hs.T:Scer\GAL4 show variegated eye colour.

      Eye colour: flies carrying both wScer\UAS and Su(var)205hs.T:Scer\GAL4 show variegated eye colour.

      Eye colour: flies carrying both wScer\FRT.d1.mut.Scer\UAS and Su(var)205hs.T:Scer\GAL4 show variegated eye colour.

      (Nakayama et al., 2007)

      Heat-shock induced expression of Su(var)205hs.T:Scer\GAL4, induces loops between the P{Winkelried}A7 insertion site and intercalary, pericentric or telomeric heterochromatin in polytene chromosomes. This effect is not seen with the P{Winkelried}D insertion.

      (Seum et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HP1GAL4DBD
      (Pokholkova et al., 2015)
      Su(var)205G4DBD.hs
      Su(var)205hs.T:Scer\GAL4
      Name Synonyms
      Secondary FlyBase IDs
        References (4)