FB2026_02 , released June 18, 2026
Allele: Dmel\PcZnF.hs.Tag:FLAG
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General Information
Symbol
Dmel\PcZnF.hs.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0124097
Feature type
allele
Associated gene
Dmel\Pc
Associated Insertion(s)
Carried in Construct
P{ZnF-Pc.R}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Roseman et al., 2001)
Progenitor genotype
Carried in construct
P{ZnF-Pc.R}
Cytology
Description

Expression of full length cDNA of Pc fused to Tag:FLAG and the su(Hw) DNA-binding domain is driven by a heat shock promoter.

(Roseman et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Pc
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early (embryogenesis) heat shock induction of Pchs.T:su(Hw)-ZnF,T:Zzzz\FLAG cause lethality.

      (Roseman et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      PcZnF.hs.Tag:FLAG is an enhancer of adult cuticle phenotype of su(Hw)V/su(Hw)E8, y+mDint2

      (Roseman et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of wBR.BR and wBR.E.BR is reduced (in a background of reduced su(Hw)+) by the expression of tethered Pc. This effect is seen without the use of heat shock. Expression of y+mDint2 is reduced (in a background of reduced su(Hw)+) by the expression of tethered Pc, Scm or esc. In the case of Pchs.T:su(Hw)-ZnF,T:Zzzz\FLAG, the effect is seen without the use of heat shock. Expression in the body cuticle is less sensitive to repression than in the wing cuticle. ph-p409 completely suppresses the strong silencing of wBR.E.BR in P{SUPor-P}22F caused by tethered Pc.

      (Roseman et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PcZnF.hs.Tag:FLAG
      Pchs.T:ZnF-su(Hw),T:Zzzz\FLAG
      Pchs.T:su(Hw)-ZnF,T:Zzzz\FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)