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General Information
Symbol
Dmel\su(Hw)E8
Species
D. melanogaster
Name
FlyBase ID
FBal0035728
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C14306458T

Reported nucleotide change:

C2109T

Amino acid change:

H459Y | su(Hw)-PA; H459Y | su(Hw)-PB; H459Y | su(Hw)-PC

Reported amino acid change:

H?Y

Comment:

Reported nucleotide numbering from FBrf0048095.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The first His residue of zinc finger 7 is changed to Tyr.

Nucleotide substitution: C?T. Amino acid replacement: H?Y. Mutation is in the seventh zinc finger.

Nucleotide substitution: C2109T. Amino acid replacement: H?Y.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

su(Hw)E8/Df(3R)su(Hw)-A1933 transheterozygotes are viable but female sterile and also lack the gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes).

su(Hw)E8/+ completely suppresses the inhibitory effect of mod(mdg4)ul on the expression of y in bristles. Completely suppresses the scD1 mutant phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

su(Hw)E8 is a suppressor of phenotype of y2

Additional Comments
Genetic Interactions
Statement
Reference

Strong suppression of the y2 phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The female sterility phenotype and the loss of gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes) caused by su(Hw)E8 is not complemented by su(Hw)A2663 and partially complemented with either su(Hw)A460 or su(Hw)M393 (both a separation-of-function allele), which restore either the female fertility or the insulator function, respectively.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)