FlyBase Allele Report: Dmel\su(Hw)[E8]

General Information

Symbol

Dmel\su(Hw)^E8

Species

D. melanogaster

Name

FlyBase ID

FBal0035728

Feature type

allele

Associated gene

Dmel\su(Hw)

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Smith and Corces, 1995, Harrison et al., 1993)

Progenitor genotype

Cytology

Description

The first His residue of zinc finger 7 is changed to Tyr.

(Kim et al., 1996)

Nucleotide substitution: C?T. Amino acid replacement: H?Y. Mutation is in the seventh zinc finger.

(Smith and Corces, 1995)

Nucleotide substitution: C2109T. Amino acid replacement: H?Y.

(Harrison et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:14,306,458..14,306,458 [-]

Nucleotide change:

C14306458T

Reported nucleotide change:

C2109T

Amino acid change:

H459Y | su(Hw)-PA; H459Y | su(Hw)-PB; H459Y | su(Hw)-PC

Reported amino acid change:

H?Y

Comment:

Reported nucleotide numbering from FBrf0048095.

(Harrison et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Harrison et al., 1993)

female sterile (with Df(3R)su(Hw)-A1933)

(Baxley et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

su(Hw)^E8/Df(3R)su(Hw)-A1933 transheterozygotes are viable but female sterile and also lack the gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes).

(Baxley et al., 2017)

su(Hw)^E8/+ completely suppresses the inhibitory effect of mod(mdg4)^ul on the expression of y in bristles. Completely suppresses the sc^D1 mutant phenotype.

(Georgiev and Kozycina, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Pc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Pc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

NOT Enhanced by

Statement

Reference

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Pc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

NOT Enhanced by

Statement

Reference

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

Suppressor of

Statement

Reference

su(Hw)^E8 is a suppressor of phenotype of y²

(Harrison et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

Strong suppression of the y² phenotype.

(Harrison et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

The female sterility phenotype and the loss of gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes) caused by su(Hw)^E8 is not complemented by su(Hw)^A2663 and partially complemented with either su(Hw)^A460 or su(Hw)^M393 (both a separation-of-function allele), which restore either the female fertility or the insulator function, respectively.

(Baxley et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Severe su(Hw) allele.

(Harrison et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Su(Hw)^E8

(Kuhn-Parnell et al., 2008)

su(Hw)^E8

(Baxley et al., 2017, Kuhn-Parnell et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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