FlyBase Allele Report: Dmel\robo2[S4-14]

General Information

Symbol

Dmel\robo2^S4-14

Species

D. melanogaster

Name

FlyBase ID

FBal0124988

Feature type

allele

Associated gene

Dmel\robo2

Associated Insertion(s)

Carried in Construct

Also Known As

lea^54-14

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Schimmelpfeng et al., 2001)

Mutagen

ethyl methanesulfonate

(Schimmelpfeng et al., 2001)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Schimmelpfeng et al., 2001)

some die during embryonic stage | recessive

(Schimmelpfeng et al., 2001)

Phenotype Manifest In

cephalopharyngeal skeleton

(Schimmelpfeng et al., 2001)

cephalopharyngeal skeleton (with robo2^lea-1)

(Schimmelpfeng et al., 2001)

embryonic somatic muscle cell

(Schimmelpfeng et al., 2001)

hypostomal sclerite

(Schimmelpfeng et al., 2001)

hypostomal sclerite (with robo2^lea-1)

(Schimmelpfeng et al., 2001)

larval longitudinal connective

(Schimmelpfeng et al., 2001)

lateral process of cephalopharyngeal skeleton

(Schimmelpfeng et al., 2001)

Detailed Description

Statement

Reference

Tracheal dorsal branch fusion occurs normally in lea^S4-14/+

(Schulz et al., 2011)

Fas2-positive fascicles (including the lateral and medial bundles) often cross the midline in mutant embryos, in contrast to wild type. The formation of longitudinal connectives is reduced. Muscle fibres frequently cross the central nervous system on its dorsal surface (this phenotype is never seen in wild-type embryos). The formation of the peripheral nervous system appears normal. Homozygous embryos have a defective head skeleton and the lateral-graten and H-piece do not form. The dorsal bridge still forms. lea¹/lea^S4-14 embryos have a defective head skeleton and the H-piece does not form. The dorsal bridge still forms.

(Schimmelpfeng et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

robo2^S4-14 has cephalopharyngeal skeleton phenotype, non-enhanceable by robo1¹

(Schimmelpfeng et al., 2001)

NOT suppressed by

Statement

Reference

robo2^S4-14 has cephalopharyngeal skeleton phenotype, non-suppressible by robo1¹

(Schimmelpfeng et al., 2001)

NOT Suppressor of

Statement

Reference

lea[+]/robo2^S4-14 is a non-suppressor of adult dorsal tracheal branch | third instar larval stage phenotype of Sdc²⁶³⁹

(Schulz et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of lea^S4-14 fails to suppress the dorsal branch fusion phenotype seen in the tracheal system of Sdc²⁶³⁹ homozygous third instar larvae. One copy each of lea^S4-14 and Sdc²⁶³⁹ does not produce any dorsal branch fusion defects.

(Schulz et al., 2011)

robo¹ lea^S4-14 double mutant embryos have a head phenotype comparable to that of lea^S4-14 single mutants.

(Schimmelpfeng et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

robo2^H1-3

(Schimmelpfeng et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: robo^unspecified.

(Schimmelpfeng et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Robo2^S4-14

(Schulz et al., 2011)

S4-14

(Schimmelpfeng et al., 2001)

lea^54-14

(Raza and Jacobs, 2016, Vanderploeg et al., 2012, Knox et al., 2011)

lea^S4-14

robo2^S4-14

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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